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Alpha Lipoic Acid for Nerve Pain
Alpha Lipoic Acid ( ALA ) can be establish in food such as liver , Brassica oleracea italica , and spinach . It is an essential cofactor for mitochondrial metabolism that has antioxidant and anti - incendiary activity . Due to these properties , Alpha Lipoic Acid can serve to protect against nerve damage and has been utilise in former diabetes to cover and prevent the forward motion of nerve pain.(3)Neuropathy , or nerve pain , associate with diabetes is often describe as a burn pain in the script and feet ( the characteristic stocking - glove distribution ) . In Europe , Alpha Lipoic Acid ( ALA ) has been used to plow diabetic neuropathy for decades . In the US , it is available as an over the counter addendum .
Research:
In the NATHAN 1 trial , 460 diabetic patients with balmy - to - moderate DN were arbitrarily assigned to receive unwritten discourse with 600 mg Alpha Lipoic Acid ( ALA ) once a twenty-four hours or a placebo ( inactive ) anovulatory drug . Patients report botheration melioration with Alpha Lipoic Acid ( ALA ) vs. the placebo pill , and the medication was well tolerated.(2)Similar results were found in other trials.(3 , 4 )
Although most of the research shows the utility of alpha lipoic acid for neuropathic painfulness , I also reviewed a study where ALA was given with omega-3 supplementation for post - partum pain management.(5)The affected role were nursing mothers , a population in which it is particularly important to attempt to avoid conventional medications due to business organization of transmission of harmful substances to the newborn . The results found Alpha Lipoic Acid ( ALA ) and omega-3 fatty acid did in fact effectively and safely reduce postpartum pain . However , this was not a large randomized trial , so further studies are needed . to boot , at this time , there are not enough studies to establish the safety of Alpha Lipoic Acid ( ALA ) supplementation in pregnant or wet-nurse women so please look up with a physician if you plan on taking them . There are additional test afoot examining the use of Alpha Lipoic Acid ( ALA ) for chronic pelvic pain , bladder pain sensation , and fibromyalgia , as well .
Some of you may be enquire how Alpha Lipoic Acid ( ALA ) compares to the more formal medicament often prescribed for diabetic neuropathy . One discipline compared ALA to conventional aesculapian treatment with pregabalin ( Lyrica ® ) or carbamazepine.(6)They encounter pregabalin had a ranking analgesic answer for diabetic neuropathic pain . Pregabalin does carry more harmful side issue , but its use would likely result in more substantial pain alleviation than Alpha Lipoic Acid ( ALA ) alone . This lends further evidence that Alpha Lipoic Acid ( ALA ) may be of more use for those in the former degree of diabetic neuropathy , or even for pre - diabetic patient who do not yet suffer from neuropathy as a preventive measure . Those with severe neuropathy are more probable to require conventional nerve medications . As a side note , for those patient suffering from hard diabetic neuropathy who have go conservative direction , there are subprogram that interventional pain doctor can perform that can provide substantial relief from cheek pain .
It is very important to note that severe diabetic neuropathy is very unmanageable to treat , thus bar with good glycemic ascendancy should always be the primary goal .
Side Effects of Alpha Lipoic Acid (ALA):
At high DOS , Alpha Lipoic Acid ( ALA ) can cause low glucose levels so diabetic patients taking glucose - lowering medications should be careful . It is otherwise well tolerated at the recommended doses . Those with thyroid gland disease and grievous alcohol utilization should be cautioned as well . I advocate hold back with your physician prior to starting any accessory , as they may interact with your current medications .
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