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As time is passing by and the pandemic still seems to be harry through the macrocosm , researchers are work round the clock to test and find mode to battle the SARS - CoV-2 , the virus that is do COVID-19 infections . It has been just a little over one yr since the fresh coronavirus was declared to be a pandemic . During this time , millions of multitude have tested positive , and millions more have die out from it . find ways to decrease the bed cover of the computer virus has been the elemental focus of researchers , governments , and pharmaceutical companies around the world . Recent research has now shown that a drug called Bepridil could be effective in treating patients with COVID-19 . However , can Bepridil , an angina drug , really do by COVID-19 ? Let ’s take a look .
Brief Look at COVID-19 Treatments
Over the last one twelvemonth , researchers and scientists from all over the world have been studying various treatments in hopes of manage COVID-19 . In the last year , over 111 million people have test cocksure for the novel coronavirus , and almost 2.5 million people have died from the infection.(1,2,3,4)In the former one year , scientists have continued to study several drugs that have been okay by the US Food and Drug Administration to sympathize if they may meet a role in abbreviate the symptoms of COVID-19 . However , only a few of these drugs have sow any actual promise.(5,6 )
For case , Remdesvir , which is a medicinal drug prescribed to people withEbola , was one of the first drugs to be approve by the Food and Drug Administration for the treatment of COVID-19.(7)Remdesivir was discover to serve slow down down the replication of the novel coronavirus in the body , thus reducing the recuperation time of 15 days to 10 days.(8 )
Another drug that has been approved by the Food and Drug Administration for other purposes but has been recover to be helpful in the handling of COVID-19 is dexamethasone . Dexamethasone is a corticosteroid that is used to reduce inflammation in the body.(9,10)Dexamethasone has been prescribed to some people with the novel coronavirus contagion who were experiencing respiratory proceeds . Ever since then , doctors have started prescribing dexamethasone to masses with COVID-19 . It has been notice that the demise charge per unit in these patients go down.(11 )
Similarly , the Food and Drug Administration had granted emergency commendation for using the drug hydroxychloroquine for the handling of COVID-19 , but the commendation has been revoke since then.(12)Apart from this , the Food and Drug Administration also warn that there were safety issues in using hydroxychloroquine for treating COVID-19.(13 )
Bepridil for COVID-19
Research from the Texas A&M University led the bepridil written report , which is release in the journal Proceedings of the National Academy of Sciences of the United States of America.(14)The enquiry team canvas 55 drug to chance a medicinal drug with prior approval from the Food and Drug Administration for finding an alternative to remdesivir . The team discovered that six medications might be effective in stop the replication of the computer virus , and bepridil showed the most promise .
Bepridil is traditionally used for the treatment of angina , which is a condition that appears when there is less than normal rake oxygen reach a exceptional part of the heart muscle.(15 )
According to investigator of the unexampled study , bepridil is a Ca blocker that has major antianginal activity . dish out a in high spirits dose of bepridil can slacken down the riposte of the virus in the server cells by increasing the pH of endosomes and also inhibiting Mpro .
This theory was tested by the research team by inject the virus in both human cadre and African green rascal jail cell . Furthermore , they also tested bepridil in three unlike concentrations . They observe that the expectant density of bepridil was effective in inhibiting the replication of SARS - CoV-2 .
On the whole , the results indicated that bepridil is effective in prevent SARS - CoV-2 from get in and duplicate in mammalian cell hosts . The study , therefore , recommend further clinical trials of bepridil for the treatment of COVID-19 .
Conclusion
It is important to have a go at it that bepridil is not yet available as a prescription drug for the treatment of COVID-19 in the United States.(16)The manufacturer of bepridil voluntarily withdrew the medicament from being sold as there were some concerns that it could have pith job . However , bepridil is still order for treat angina in country like China , France , and Japan .
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