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Bipolar Disorder is a psychiatrical aesculapian status characterise by inveterate and recurrent episodes of natural depression and mania or hypomania . The symptom ofBipolar Disordergenerally can be see at a very early eld with the average being around 20 year . The ascendent reason of bipolar disorder is still not yet known but researchers believe that certain genetic and environmental factor play a theatrical role in the development of this condition . Additionally , researchers have receive out an important use of dopaminergic arrangement in the development of bipolar disorder . This is because the most unwashed dopaminergic drug levodopa has shown to cause episodes of cacoethes and hypomania in masses with bipolar disorderliness . These episode however tend to improve with the disposal of antipsychotics.[1,2,3 ]
Researchers have also discover grounds that suggests that moving from a manic to a depressive state in mass with bipolar occurs in sync . There is also evidence that the switch from a depressive to a manic state pass off concurrently with an step-up in dopamine receptors . Parkinson diseaseon the other hand is a step by step reformist disease of the brain that make degeneration of the brain cells resulting in the symptoms of tremor , inflexibility , vitiate and restricted mobility , and problem with speak , swallowing , and balance . According to the National Institute of Health the risk of getting Parkinson disease increases with age.[1,2,3 ]
People with Parkinson ’s disease usually take a drug called levodopa to help slacken the degeneration of the brainpower which has been known to cause an increase in the symptoms of bipolar disorder as mentioned above . to boot , the intervention for bipolar disorder includes medicine like lithium and antipsychotic medications which are tight associated with drug induced Parkinsonism which is quite similar to Parkinson disease in price of the symptoms that it make including bradykinesia , rest tremor , muscle rigidity , and postural instability.[1,2,3 ]
Since drug rush Parkinsonism is quite common in multitude with bipolar sometimes physicians misdiagnose Parkinson disease as drug induced Parkinsonism . Unlike bipolar disorderliness , Parkinson disease is far more coarse in the elderly population . There have been some studies which show that bipolar disease incline to be seen more in hoi polloi with Parkinson disease when compared to the general population.[1,2,3]The clause therefore highlights whether bipolar disorder can cause Parkinson disease .
Can Bipolar Disorder Increase The Risk Of Parkinson Disease?
A recent cogitation has revealed that citizenry with bipolar disorder are really at an increase risk of exposure for formulate Parkinson disease . This risk is magnify with increasing asperity of bipolar . To investigate the inter-group communication further , researchers from the Taipei veterans General Hospital go plump deeply into this determination . The findings of their enquiry have now been published in the diary name Neurology . The investigator analyzed the health records of about 56,000 people with a know diagnosing of bipolar disorder in Taiwan . The people that were choose were diagnose between the long time 2001 to 2009 . The data of these individuals was then compared with the health records of about 225,000 people who had no diagnosing of either bipolar disorder or Parkinson disease.[3 ]
The health status of both the radical was closely monitored through 2011 . After a tightlipped analysis , the researchers found out that about 0.7 % of people with bipolar disorder croak on to develop Parkinson disease during the study and only 0.1 % of the people in the control mathematical group had it . To realise their determination the researchers then adjusted their data by taking into invoice the past aesculapian and medicinal drug history , age , sexuality , or history of any mind injuries which all could have a possible bearing on the development of Parkinson disease.[3 ]
After making all the necessary adjustments , they came to the conclusion that the peril of a person developing Parkinson disease was approximately 7 times more in people with a known diagnosis of bipolar disorder than the general universe . Another significant finding was that the mean age of mass who had bipolar disorderliness and by and by on developed Parkinson disease was much less at around 64 years in median when compare to people who did not have a history of bipolar disorder at around 73 years in average.[3 ]
The researchers also found that the severity of the bipolar upset also had a major role to play in the development of Parkinson disease . The people who had to repeatedly go to the hospital for treatment for bipolar disorder were at the high risk for developing Parkinson disease than others . It was noted that people who give way to the hospital at least twice a year for bipolar upset were four times more at risk for Parkinson disease than people who had few hospitalization insurance for bipolar . This risk increased to about 6 time in people who were hospitalize more than twice per year for handling of bipolar disorder.[3 ]
However , there are sure loopholes or limit of the study channel by the researchers from the Taipei Veterans general Hospital . The first affair was that the researchers included only those people in the subject who took medical help for treatment of bipolar disorder . Such people are quite few as many hoi polloi avoid going to a physician for this condition.[3 ]
The second limitation of the study was that the researchers did not take into account any family chronicle of Parkinson disease and other environmental agent that may increase the risk of developing Parkinson at a later old age . The researchers states that more such studies are required to study whether there is any mechanics that is common for both bipolar disorder and Parkinson disease that may explicate the tightlipped connection between the two conditions.[3 ]
They consider that genetic make-up , inflammatory processes , or disruption in transmitting of signal from the brain may have a role to play here . They consider that once the cause of this connection between bipolar disease and Parkinson is found then it will go a long style in helping find treatments that would be effectual for both these conditions.[3 ]
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