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Kawasaki disease is characterise by the inflaming of blood vessels throughout the body . The main feature of the disease is high fever which lasts for more than 5 daylight and does not sink even after normally used antipyretic which is followed by peel of skin . The lymph nodes across the neck opening are enlarged , there will be rashes , reddening of eye , lips , medallion , and fillet of sole . The roue vessel which supplies blood to the eye becomes inflamed resulting in swelling of the coronary arteries and in the long run it stimulate coronary arterial blood vessel aneurysms within a couple of age . There will be unnatural dilatation of coronary arteries . In acute form of the disease , there will be systemic inflammation affecting many organ of the trunk causingmyocarditis , pericarditis , asepticmeningitis , arthralgia , arthritis , pneumonitis , lymphadenitis , and hepatitis . There will be an increased telephone number of white blood cells in the body argue rubor .

Can Kawasaki Disease Cause Aneurysms?

Kawasaki disease if left untreated causes heart diseases in 1 % of the population and coronary aneurism if occurred can not be recovered . Such patients are at increase risk of myocardial infarct and death . Timely treatment can prevent cardiovascular events.(1 )

Kawasaki disease can be fraction into three clinical phase ’ acute febrile phase , sub - acute phase and recovery phase . The sharp phase is characterized by high febrility , erythema , swelling of hands and foot , aseptic meningitis and diarrhea . Myocarditis can encounter during this fourth dimension . There will be symptom of coronary arteritis and pericardiac effusion . Aneurysms may not be diagnose during this phase . Sub - acute phase starts when fever , rash and lymphadenopathy symptoms begin to subside which usually take up to 2 calendar week . There will be peeling of the pelt of fingers and toes . Subacute phase angle has coronary arteria aneurysms . There will be an increased risk of death due to meat failure . This will be followed by a recovery phase where all the clinical sign of Kawasaki disease melt and the body return to the convalescence phase.(2 )

Heart disease is the main complications of Kawasaki disease . It is one of the main heart disease that happen in children in the United States and Japan . Coronary artery aneurysms pass off in tiddler due to vasculitis in up to 25 % of the patients . The aneurysms are diagnosed after 10 days of the attack of the disease and usually happen within 4 workweek of disease onset . depend upon the extent to dilatation of the coronary artery , the aneurysm can be classified into small-scale , medium , and giant . Saccular and fusiform aneurysms develop within 18 - 25 days of the onset.(3 )

The treatment of Kawasaki disease is started after 5 day of onset of the disease and it is rede to start treatment after 5 daylight only . The treatment is comprised of gamey - dose IVIG and febrifuge . 5 % of the patients even after discourse proceed to modernize transitory coronary artery dilation which can further develop into giant aneurysm . The death in such suit results due to myocardial infarct , a blood clot in the aneurism or rupture of the same . Death due to aneurism can happen within 12 weeks of malady . The potential causes of aneurysm include low hemoglobin , low albumen , increases WBC , high CRP denseness and historic period less than one yr . The recovery of aneurysm usually happens within two age of dilatation . The blood watercraft starts narrowing as part of the healing process , the constriction of the line vessel diminish the supplying of oxygen and blood to the middle resulting inmyocardial infarction.(4 )

Aneurysms can be treated by percutaneous transluminal angioplasty , bypass graft , coronary arteria stenting , and even cardiac transplantation . The extent of recovery depends upon the size of it of aneurysm

Echocardiogramand angiography help in the diagnosing of aneurysms in Kawasaki disease . The visible symptoms settle on their own , but the warmness disease requires intervention which can reverse fatal . In general , nestling with Kawasaki disease will have a bad cardiovascular profile with high rakehell air pressure , increased weight and high cholesterol levels .

Conclusion

One of the major life - menace knottiness of Kawasaki disease is aneurysm . There will be dilation of the blood watercraft and while healing the constriction of the vas decreases the supply of atomic number 8 and blood leave in myocardial infarct and death . The size of the aneurysm determines the intensiveness of damage .

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