Liver fibrosis is the excessive scarring of liver tissue due to progressive liver inflammation and liver cell last in continuing liver diseases . It happens when liver try out to repair its damaged cells through deposition of newfangled collagen fibre . This deposition of repaired tissue upshot in hempen tissue formation . This exaggerated wounding healing reception interferes with normal liver routine .
Liver fibrosis occurs due to retell damage due to various drug or disorders . The hepatocytes are offend due to trauma , excess alcohol white plague , toxin , hepatitis B , hepatitis C , bilious obstructer , autoimmune hepatitis , non - alcohol-dependent roly-poly liver disease , and Wilson ’s disease . However , very seldom liver fibrosis is the elemental trouble , mostly it is secondary to other liver diseases .
The stages determine the degree of damage to the liver . The bodily function or the prediction of how fibrosis is progressing is done based on a pop scoring system send for the METAVIR scoring system . The fibrosis arrange range from F0 to F4 . F0 staging show no grounds of fibrosis , F1 leg depicts portal fibrosis without any septum establishment , F2 stage is portal fibrosis with few septa formation , F3 stage shows various septa , but without any cirrhosis , F4 leg depicts liver fibrosis . The most severe form of liver fibrosis include F3 and F4 stages .
The initial stage of fibrosis is symptomless , but when present , symptoms include tiredness , lethargy , departure of appetence , nausea , disgorgement , acerbity , mental confusion , and accruement of fluid in the legs and stomach . Mostly the symptoms are those of liver cirrhosis of the liver . The brain social occasion deteriorate due to inability of the damage liver cells to permeate toxic heart from the blood , which in turn build up in the pedigree and make the brain .
Can Liver Fibrosis be seen on Ultrasound?
It is hard to diagnose liver fibrosis in the early stagecoach , as there are no light symptom in the beginning . presently , biopsy is the gold monetary standard for diagnosis of liver fibrosis , but there is advent of novel , non - incursive ultrasound proficiency that can be used to discover liver fibrosis , thus an ultrasound can be used as a diagnostic aid in detecting liver fibrosis . The diagnosis is potential only in the late stage when the demolition of liver progresses and symptom start pass ; however , there is on-going research for other diagnosis of liver fibrosis to improve the medical prognosis of liver disease .
Ultrasounduses sound wave to bring forth range of a function that show the size of it and shape of the liver . It also shows the blood menstruate through liver . The liver with sclerosis will look lumpy and shrivel up on an ultrasound image . There are various echography that can be used to notice fibrosed liver . These include bidimensional grey - scale of measurement echography , color and exponent Doppler ultrasound , pulse wafture Doppler ultrasonography , gamy frequency grey - scale ultrasonography , acoustic irradiation effect impulse imaging ( ARFI ) , active demarcation - heighten ultrasound and transient elastography . transeunt elastography(TE ) , acoustical radiation force impulse imaging ( ARFI ) and shear wave elastography ( SWE ) are all peculiar non - invasive techniques , which give elaborate study of the liver and if used in the first place , further the need of liver biopsy can be rule out . It can observe liver elasticity ( stiffness ) far more early than other imaging techniques .
Transient elastography ( FibroScan ) is a monodimensional ultrasound that was introduced in market in early 2000s and is currently the most pop non - invasive symptomatic aid for liver fibrosis and cirrhosis ; however , it is more exact for liver cirrhosis . Its limitations include obesity , ascites and manipulator inexperience . Sonoelastography utilize 2D - elastography technique and tangible time elastography technique ( RTE ) are also being used to diagnose liver fibrosis , but are less accurate in detecting staging of liver fibrosis than TE . Acoustic radiation military force impulse imaging ( ARFI ) truth is comparable to TE in the diagnosing of fibrosis and cirrhosis . Shear moving ridge elastography can image liver stiffness in real time and it has been gas to have better performance than TE for the diagnosing of TE , but further establishment is required in this bailiwick .
There are other diagnostic approach includingCT scan , MRIand liver biopsy for further diagnosis and verification of liver fibrosis .
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