This article on Epainassist.com has been reviewed by a medical professional , as well as checker for facts , to ensure the reviewer the best possible truth .
We follow a strict editorial insurance policy and we have a zero - tolerance policy regarding any level of plagiarization . Our articles are resourced from reputable online pages . This clause may hold scientific references . The number in the excursus ( 1 , 2 , 3 ) are clickable links to equal - retrospect scientific papers .
The feedback link “ Was this Article Helpful ” on this page can be used to report content that is not accurate , up - to - date or questionable in any manner .
This clause does not leave medical advice .
Narcolepsy is a term which does not go forth . Currently , there is no cure but symptoms can be effectively managed . The cure is not possible due to irreversible damage to neuron present in the hypothalamus .
Can Narcolepsy Go Away On Its Own?
Narcolepsy is a chronic neurological condition . This consideration does not go away and can only be managed through medicament . Fortunately , the condition is non - progressive or has slow progress and symptom do not worsen in most of the patients .
Narcolepsy is the term in all probability caused due to resistant scheme triggered throug various mean such as infection . As the contagion contracts the soundbox , it stimulates the resistant system to drink down the healthy brain cells . Thus , the resistant system targets the nerve cell of the hypothalamus . These neurons are know to secrete hypocretin ( also known as orexin ) . Hypocretin is a chemical substance that regulates the quietus - wake cycle . harm to the nerve cell release hypocretin cut down its concentration in the cerebrospinal fluid ; as the experimental condition progresses , almost 60000 to 70000 nerve cell of the hypothalamus get destroyed1 .
The level of hypocretin compass to even zero because of the complete destruction of hypothalamus neurons . The level of hypocretin in cerebrospinal fluid is diagnosed with a proficiency known as lumbar puncture .
The person who has zero hypocretin floor in the cerebrospinal fluid suffered fromcataplexy . This is the condition characterized by weak heftiness tone . The mesomorphic weakness is austere and the affected role falls on the level without losing conciousness2 .
It is to be noted that the regeneration of neurons is a very rare phenomenon . Thus , once the hypocretin - produce nerve cell of the hypothalamus get damaged , they can not be revived . This makes this precondition lasting . Further , the experimental condition should also be manage through dour intervention .
Research is on to either obtuse or foreclose the death of hypothalamus cellular telephone and regenerate them . Growth of hypothalamus neuron though stem cells is another possibleness in the near future . However , in the present scenario , narcolepsy remain a chronic circumstance which remains forever with the patient .
Treatment Of Narcolepsy
Various discourse options are uncommitted for the patient to superintend the symptoms of narcolepsy . A most common symptom of narcolepsy include inordinate daytime sleepiness , cataplexy , behavioral changes , and hallucination . On the groundwork of the severity of symptoms , the treatment strategy is plan . The right treatment strategy is a must to prevent the patient to chance fateful accident . Many nation have limitation on concede the driving license to patients with poorly bring off narcolepsy .
Antidepressants . Tricyclic antidepressants such as imipramine , desipramine , and clomipramine are used to control the impression . These drug are also effective in verify symptoms of cataplexy3 . Antidepressant may not be tolerable to some affected role due to its side consequence .
upper - Like stimulation . When modafinil and armodafinil are not effectual in treating narcolepsy , the doctor may prescribe amphetamine - similar stimulant drug such as methylphenidate3 . These drugs are used to ease excessive day time sleepiness . The habit of these drug should be monitor due to their side effects . Common side outcome let in to-do in cardiac rhythm , commotion in nighttime eternal sleep , choler and nervousness .
Modafinil . Modafinil and armodafinil are broadly speaking order as stimulants to keep day time quietus . These are broadly speaking the primary discussion for narcolepsy . Non - additive and predictable pharmacokinetic profiles are some of the advantages of these stimulant over older stimulants4 .
SSRIs And SNRIs . These drug are used to manage a variety of symptom link up to narcolepsy . These drugs oppress the REM sleep , hallucination , sopor palsy , and cataplexy4 .
Sodium Oxybate . Sodium oxybate is used to prevent cataplexy and day clip sleepiness5 . The drug is also effective in promoting nighttime nap . Clarence Day prison term sleepiness is more effectively verify through high back breaker of this drug .
Conclusion
Immune system damages the hypothalamus neurons which are responsible for for secrete hypocretin . This chemical ascertain sleeping behavior . Various treatment options are available for treating narcolepsy such as antidepressants , stimulants , amphetamine - comparable stimulants and sodium oxybate .
References :
Also Read :
