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Neurofibroma is a three - word compounding meaning cheek , sinewy tissue and tumor . Neurofibroma is a tumor spring from the multiplication of neural or perineural tissue . commonly , the neurofibromas are of benignant origin with minimum symptoms and occur singularly without any correlation coefficient with other systemic symptoms whereas neurofibromatosis occurs with a group of symptom one of which can be the formation of neurofibromas .
Can Neurofibromas Become Cancerous?
Neurofibromas are very benign neoplasm with a soft consistence and no local spread . But not always are these benign , they can also turn into cancerous lesions especially when associated with one of the von Recklinghausen’s disease eccentric . Plexiform neurilemoma which is a character of neurofibromas is characterize by continuous emergence , increased involvement of local tissue and widespread neurologic deficit[1 ] .
Plexiform neurilemoma is commonly seen turn into cancerous neoplasm because of their progressive nature . Invasive neurofibroma are lesser - known but not uncommon . Malignant changes are seen with local tissue paper involvement and metastasis to remote tissues . Usually , the tie with other tumour like optic glioma ; vestibular schwannomas , etc . is the more consistent feature article in the malignance of neurofibromas .
operative resection is the intervention of choice for neurofibroma . Scarring can be run across after the healing of the defect created during surgery . This scar tissue sometimes acts as triggers for recurrence and helps the neoplasm to undergo malignant transformation .
Does Neurofibromas Get Worse With Age?
Even being benign , the neurofibroma tumor are reform-minded in nature and rise on with boost age[2 ] . neurilemoma with the size of a pea at a young age can change state to the size of a walnut in old age . These also reproduce in numbers to describe the extent of disease , progression of the disease , and sometimes malignancy of the tumors .
According to the research project on neurilemoma and associated disorders , it is realise that these exacerbate over a catamenia of meter and with pass on age . If left untreated these can outgrow in number and can be very troublesome for the patient role . Also after the treatment is not sought for them , there may occur necrosis within them due to the tone-beginning of the resistant organization on them and the necrosis can easy turn the benignant lesions into malignant one .
Although the age of presentation is more in puerility and teenage with the antecedently known cases of the disorder in the family , it also realise the disease more dangerous with clock time due to undergoing progression and worsening . The neurologic shortage because of neurofibroma tumors also increases due to the involvement of nearby nervousness bundles in it . The times of these tumors is common elderly mass and has a much high bit of tumors than the young patients who just have got the early symptoms of the disease with one or two tumors . The environmental triggers and agent are encountered by the passing age and hoard in the dead body which may work in favor of advancement of the neurofibromas .
Also , the multiple neurofibromas are stimulate a very bad enhancive appearance and prove prejudicial to the lineament of life . The treatment becomes unmanageable with the geezerhood because of multiplicity , lowered immunity and healing power of the body .
Conclusion
Benign nature of the neurofibromas is not a invariant feature article of it , as plenty of cases is seen getting converted into invasive and malignant tumors . Radiation exposure , environmental triggers , advancing years and severeness of the association are some of the common factors responsible for the cancerous conversion . It could be detected by the biopsy from the tumors or tax the resected part of the tumor .
Age progression has show to be damaging for the tumors and these are not belonging to the chemical group which gets corrected itself by the age . Worsening with historic period has been prove by various studies and it points towards the need for early intervention in the disease . Early diagnosis and treatment of the tumor are necessary if high peril of malignancy is surmise . Unnecessary delays are not part of the Wisdom of Solomon in the treatment of neurofibroma .
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