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read/write head and neck paragangliomas are parasympathetic that mostly occur at the carotid bifurcation but also along the vagal nerve and in the secular bone.(1 )
Can You Die From Paraganglioma?
It is a neuronic cubicle tumor that occur in reception to familial aberrance and mutations occurring during the embryogenesis within the totipotent cells of the embryo . there can be the geological formation of such abnormal cells but it may maturate by and by on to present in the middle phase of life .
Paraganglioma itself is not a dangerous shape because it is limit to one site only and there is not much of spread pass in it . But it ordinarily is locate on crucial sites where it take off give rise symptoms like carotid artery bifurcation , skull base , etc . So , whenever it ’s starts raise symptoms it is very much necessary to eviscerate the tumour and that is why surgical treatment is the first - line treatment for any paraganglioma .
But in rare typeface , there may be malignant shift occurring leading to multiple tumor geological formation in the body and surgical treatment may not be sufficient to eviscerate all tumors and completely cure the disease . In such cases , the prognosis becomes wretched , and the patient role and die of the condition .
OR for a paraganglioma is very grave and can head to destruction in various cases . According to a report publish in the US , surgery of a carotid body tumour in about 4000 case result in 2 % of mortality killing about a hundred people . When the surgery for the same condition was also associated with the remotion of a part of the carotid artery also known endarterectomy then the mortality increase from 2 % to 8.5 % ( 2)So , it is very much potential that a affected role can die on the surgical process table even when the condition has such a successful cure pace and intervention .
How Do You Stop Paragangliomas From Spreading?
Usually , a paraganglioma does not diffuse either locally or metastatically but is it gets converted to malignant build , and then it can start spread to various parts of the consistence . In such character , surgical treatment is not the discussion of option but the combination of various drug can be start to reduce the chances of bed covering and heal the tumor .
Only a few of the drugs are known to be in force against a scatter paraganglioma and can command it to some extent . The pharmacologic combination therapy give in paraganglioma consists of three drug mainly , cyclophosphamide , Oncovin , and dacarbazine.(3)Many case have been regressed by this combination of drug and are specially effective in pheochromocytoma which is a paraganglioma of the adrenal secretor . Another drug that is efficient in such cases that are resistant to this triple therapy is make out as temozolomide . But it is to be used very carefully and only in resistant cases of pheochromocytoma .
Conclusion
Yes , there is a natural that a patient who is get from any kind of paraganglioma can also die from that condition . Although being a very benign disease , it is very much treatable but due to its crucial locations , it becomes very of import to carefully resect the tumour and discharge the surgery successfully . Because in many cases it has been construe that patient has died upon the operating mesa because of additional effects and risks borne by all the operating room .
Malignant transformation of paraganglioma has also to be controlled because it can head to the production of a assortment of hormone in the consistency and also increases the peril of death from the malignancy if left untreated . Once the tumor has turned malignant , the choice of handling becomes pharmacological instead of surgical .
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