What is Castleman Disease?
Castleman Disease is a comparatively uncommon disorder of the lymphatic system in which there is an unnatural growth of cells . Castleman Disease is also known by the name of Giant Lymph Node Hyperplasia . There are essentially two types of this disease which are the unicentric and the multicentric . The treatment of Castleman Disease look on the type of the disease the individual has and the rigourousness of it . Surgery is usually the preferred form of handling . If Castleman Disease come about individuals already suffering fromHIV infectionthen this disease may take a turn towards the worse and can become lethal , especially in the multicentric form of this disease . Castleman Disease can also go on in case when an individual is suffer from a cancerous situation like a lymphoma .
What Causes Castleman Disease?
The root causal agency as to what causes Castleman disease is still a mystery , although some studies hint that it is due to a herpes virus knows as HHV-8 . This HHV-8 virus is also known to be a complication of AIDS . Studies suggest that the virus HHV-8 is found more in masses who have from HIV / AIDS than who do not have it .
What are the Risk Factors for Castleman Disease?
There is no specific risk factor for Castleman Disease . It can feign anyone but broadly it strikes people who are above 35 old age of age . The multicentric shape of this disease dissemble hoi polloi who are more than 50 years of geezerhood . Multicentric form of Castleman Disease is establish more in males than females . The only apparent risk divisor for Castleman Disease as of now is any person having HIV / AIDS .
What are the Symptoms of Castleman Disease?
The symptoms of Castleman Disease depend on the type of the disease the affected role has . As say , there are two form of Castleman Disease which is the unicentric and the multicentric type . In unicentric type of Castleman Disease , only one lymph node gets affected where as in the multicentric type multiple lymph node are affected . Some of the symptoms experienced by mass strike by Castleman Disease are :
How is Castleman Disease Diagnosed?
In most of the caseful of Castleman Disease , the diagnosis is made apropos when tests are being conducted to rule out some other condition . In case if Castleman Disease of any case is suspect then the following test may be place to confirm the diagnosis .
roue Tests : This mental testing will be done to retrieve if there is an infective process going on in the body and also to see if there is front of any anemia causing the symptom . This test at times identify mental defectiveness in the origin protein which is a characteristic feature of Castleman Disease .
MRI / CT Scans : imagery trial are quite a utilitarian tool in identifying Castleman Diseases it can easily name any abnormal enlargement of the lymph nodes and can help in conform the diagnosis of Castleman Disease .
Lymph Node Biopsy : This can be done to rule out other disease and differentiate Castleman Disease from other diseases .
How is Castleman Disease Treated?
Treatment of Castleman Disease calculate on the type of disease the patient role has . In cases of Unicentric Castleman Disease , since only one lymph node is involved it can be surgically compensate by slay the diseased lymph knob . In lawsuit of the disease lymph node is situate in a position where it can not be surgically removed , then medications may be give for shrinking the morbid lymph node and then eliminate it . This is best done using radiation therapy . Since reversion are vulgar in this form of Castleman Disease hence frequent followups and imaging studies are recommend .
When it come in to Multicentric form of Castleman disease surgery is not the treatment of pick as there are multiple lymph nodes that are involved , although it is seen that a splenectomy is quite effective in eradicating most of the pathologic lymph node . In such cases , medication and alternative therapies are used for controlling the symptoms but again it calculate upon whether you just have Castleman Disease or is it in compounding with HIV / AIDS which is often the display case . Some of the choice for treatment for Castleman Disease are :
