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Corticosteroid - induced osteoporosis , as the name suggests , the results due to sustain usance of corticosteroids.1There are a good phone number of corticosteroid available few of which may let in cortisol , methylprednisolone and prednisone , which are used by the patients who hurt with inflammatory conditions like muscle and joint pain , rheumatoid arthritis , GI problems like inflammatory bowel disease and respiration problems .
While corticosteroids help in suppress the inflammation , if used over a farseeing full stop of time they sway with them some stark side - upshot , one such being osteoporosis . corticosteroid cause a step-down in preoccupancy of atomic number 20 by the torso , which take to develop down of old pearl tissue paper and prevention of new bone formation ultimately leading to osteoporosis or loss of bone density.1
Causes and Risk Factors of Corticosteroid Induced Osteoporosis
A human body ’s performance involves both operation of unexampled ivory formation and breaking down of older bone . It depends on the body ’s power as to how it can equilibrise between these two processes and form dim and strong bone . One of the majors side effects of corticosteroids is that they cause a diminution in absorption of atomic number 20 by the human torso , which leads to break off down of honest-to-goodness bone tissue and bar of newfangled off-white formation thus ultimately leading to osteoporosis or loss of bone compactness .
Signs and Symptoms of Corticosteroid Induced Osteoporosis
The first signs of corticosteroid - induced osteoporosis may be easy fracturing of the hip or wrist . condensation fractures in the spine due to inability of the bones to birth the normal pressure of being in upright military strength in an individual is another strong indicator of osteoporosis . Other symptom admit sudden spartan pain in the back and loss of height .
Since osteoporosis is a do it side effect of corticosteroids , ivory density level involve to be monitor periodically as soon as the patient jump on corticosteroids to have a good control on the condition .
Tests to Diagnose Corticosteroid Induced Osteoporosis
A complete subjective and physical exam is necessary to name the condition of adrenal cortical steroid - induced osteoporosis . Typically , a DEXA CAT scan is required for measuring pearl density .
Since osteoporosis is a known side core of corticoid , the bone density levels postulate to be monitor periodically as soon as the patient starts on corticoid to have a good control on the condition .
Treatment for Corticosteroid Induced Osteoporosis
The first and foremost stone’s throw toward treatment is to strain to bring down the amount of corticosteroids being used , and much well if they can be exchange with nonsteroid medications . Given below are few of the treatment modalities used to treat corticosteroid - induced osteoporosis .
Hormone Replacement Therapy ( HRT):Hormone replacement therapy commonly help oneself in preventing osteoporosis in women.2However , this may also let in side effects such as increased hazard of gallbladder job , blood clots and heart disorders . endocrine replacement therapy when taken with the combining of oestrogen along with Provera acetate like Prempro for protract period may increase the risk of breast cancer .
If hormone surrogate therapy does not work suitably for corticosteroid - induced osteoporosis then other drug that help in slow down down pearl loss and increasing bone denseness may include :
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