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fungous nail infection , scientifically , it is known as Onychomycosis . It is characterized by discoloration , detachment , and thickening of nails . If leave uncared , it can become brittle with an irregular control surface . In simpleton , it is delimit as dystrophy of toenail and fingernail which cause embarrassment and discomfort to bear on individuals . Onychomycosis always relate with nailpsoriasiscan cause psychosocial problems . This problem is not as severe as such , but it does not solve without discourse , can be convey from nail to nail and even between individuals . Nail hurt will also increase the risk of infection of fungous infection of the affected nail , especially in the geriatric population(1 ) .
Does Kerasal Cure Nail Fungus?
Yes , the proportion of answer containing propene glycol , urea , and lactic acid bring around patients and improve their Nail Fungus conditions . With statistically significant difference versus placebo intervention from 2 weeks until the end of the study at 26 weeks(5 ) . After 4 weeks of intervention , discolouration , node , and softness each indicate improvements in patients . pelt irritation and other adverse effects were moderate and clinician ineffective to make up one’s mind to be concern to K101 - 03 in that sketch . To successfully cure toenail onychomycosis requires long treatment duration that may extend to a full year . Even then , utter cure , defined as clinical cure ( imply nail clearing ) plus mycological therapeutic ( both negative microscopy and dermatophyte culture ) , is often unattainable(7 ) .
What Is Kerasal?
Kerasal is a marketed topical discussion hold in propylene glycol , urea and lactic acid(2 ) . It is well known as K101 or Kerasal Nail ™ ( K101 - 05 ) in the market(3 ) . It has render good efficacy and tolerability in clinical probe . A study say that K101 - 03 grow rapid improvements in the patients ( 92.2 % ) after continuous 8 calendar week of intervention in their fair game nail(4 ) . There was grounds available that K101 - 03 was well tolerated in patients with onychomycosis or nail psoriasis and rapidly improved their nail .
However , treatment - related adverse event ( side effects ) were observed in some patients inonychomycosispatients process with Kerasal Nail . K101 - 03 is a marketed Ethylenediaminetetraacetic Lucy in the sky with diamonds ( chelating agent ) containing derivate of K101 in which some of the propene diol has been replace with glycerol to increase viscousness and thus make software well-situated .
Fungal Profile
Onychomycosis is an infection of the nail setup by dermatophytes , barm , or molds . Increased prevalence in recent years is attributed to enhanced longevity , comorbid conditions such as diabetes , avid play participation , and the emergence ofHIV . Dermatophytes are the most commonly entail etiologic agents , specially Trichophyton rubrum and Trichophyton mentagrophytes var . interdigitale , followed by Candida species ( C. parapsilosis , C. guilliermondii . C. albicans ) and non dermatophytic molds ( Fusarium Sp , Scopulariopsis brevicaulis , Aspergillus fumigatus , Acremonium spp . , Chrysosporium pannorum , Neoscytalidium dimidiatum , Arthrographis kalrae , Chaetomium globosum as well as T. interdigitale , and Chaetomium globosum)(6,9 ) .
Risk Factors for Toenail Onychomycosis
Nail symptoms arise in 10–60 % of patients undergo anticancer treatment . immune suppressant drug agents can damage the nail dental plate . The most usual malignance affecting the nails are squamous cell carcinoma andBowen ’s disease(8 ) . The most dominant predisposing peril element for grow onychomycosis is advanced age . Men are up to three time more likely to have onychomycosis than char . These infections can be transmitted within the family , for instance , in the plate bathtub , either horizontally ( from one spouse to the other ) or vertically ( across generations ) .
Conclusion
Kerasal is a marketed topical treatment incorporate propene diol , urea , and lactic acid . 8 weeks of intervention of Kerasal in nail fungus affected role have express much advance in their object nail . Improvements take off from 4 hebdomad of treatment . There was no discourse - related adverse effect in many study . They are effective , well tolerated , and affected role - well-disposed . K101 - 03 ( Kerasol TM ) chop-chop improves the nails of patient role with onychomycosis and/or nail psoriasis . Thus , it helps to alleviate embarrassment and stigmatization in patient with these weather condition .
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