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Sir James Paget first described Paget disease ( PD ) of the boob in 1874 . In 1881 , Thin illustrate the first histologic description of Paget ’s Disease.(1 )
Mammary Paget ’s disease pass almost exclusively in women ; involvement of the male breast is rarely reported.(1 )
How Common Is Paget’s Disease Of The Breast Or Is It A Rare Disease?
Sir James Paget ’s disease of the breast is a uncommon disease that was first described by Sir James Paget in 1874 in a female person associate with underlying breast cancer . It is a very uncommon disease with a very low incidence in the general population . It is almost exclusively found in females and is very uncommon to feel a case in males . Sir James Paget ’s disease of the boob is almost 100 % tie in with rudimentary breast cancer . It may be an ahead of time staged in situ cancerous tissue paper in 10 % of the case but in almost 90 % it is ordinarily associated with infiltrating form of cancer of the breast .
When talking about thatbreast cancer , according to many studies it is found that between one to four per centum of the total figure of cases of breast malignant neoplastic disease are found to be associated with Paget ’s disease of nipple or bosom which is not a huge amount but still has get strong tie with underlying breast cancer . Male Paget ’s disease of the breast is very rarely spot , like one in the guinea pig of address cases of prostate gland cancer with hormonal therapy . If it has to be quantified then it would make less than 1 % of the total cases that are found in female person .
The long time of diagnosis for Paget ’s disease of the breast varies widely with a range from the earliest event being reported at the years of 24 years and the modish case being report at the age of 84 years . The mean geezerhood of diagnosis of Paget ’s disease of the tit is about 55 years and the norm are about 52 to 58 year . It is found to be subsequently in cases in which there is not much development of boob cancer and it is in situ but it is find sooner by about 10 eld in cases where there is the ontogeny of infiltrate physical body of titty cancer.(1 )
In another study , it has been find that almost all the cases of Paget ’s disease of the breast diagnosed after the long time of 50 year but few of them are also diagnosed as early as at the age of 20 . According to the same written report , the mean age has dislodge from 55 years to 62 year .
The prognosis of the disease in association with the Paget ’s disease of nipple or breast is very varying and depends upon many factors which comprise of the presence of mass upon diagnosing , the intimacy of lymph thickening , the affair of other organs , etc.(2 )
Conclusion
fit in to almost all the research available on Paget ’s disease of the nipple , it is found that it has been colligate with very abject relative incidence even in the cases of breast cancer and which is even low in the worldwide population . To be exact about the incidence it is come up at the pct of 1 to 4.3 % in the female take breast genus Cancer and is even lower in cases of males . The overall number of cases is also very much humbled in Male because of its almost sole tie found in females . The mean age of participation and sensing for diagnosing was found to be about 55 year in earlier study radical but now it has shifted more towards the above 60 age group . The natural selection rate is dependent upon the grading and categorisation of breast malignant neoplastic disease which is found mostly in the association with Paget ’s disease of the nipple .
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