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Influenza is one of the vulgar grounds of myocarditis . Myocarditis is the condition characterized by the contagion of muscle of the fondness . Flu causes myocarditis through various mechanism .
How Does Flu Cause Myocarditis?
Direct Viral Cause . The toxin secrete by the virus causes damage to the muscle cells of the heart . The continuance of this damage is approximately within three days of the transmission . The defense mechanism although slows the process of viral replication , but the replication of the virus in the heart muscles is sufficient enough to stimulate severe cardiac decompensation , and that too at a speedy rate . The factors that pretend the rate of this harm are age , exercise , and nutrition . Although other factor such as maternity and status of sex hormone play their part in the development of myocarditis , the not significant factors persist the resistant system . If the resistant system fail to see the initial form of viral replication , then it may run to cardiomyopathy . The inquiry has concluded that the presence of viral genetic material is sufficient to cause wrong of cardio muscularity and is capable of interrupt the filamentlike structure of the protein and this effect is independent of the myopathy stimulate by the resistant system.(2 )
Indirect Immune Cause . The bar of viral sound reflection by the immune system sit both the prescribed as well as electronegative result in circumstance to myocardial health . As before long as the computer virus invade the body , the cells that response early are the Natural Killer ( NK ) mobile phone . Studies indicate that small level of innate killer cells stimulate increased severity of myocarditis . However , along with the NK cells , the NK - corresponding cellular phone are also produced . These cell damage the cardiac muscles by release a substance known as perforin . After the output of NK cellphone , the jail cell get by the immune system are liothyronine - cells . These cell pour down the virus present in the myocytes , do damage to the myocytes themselves . This is done due to molecular mimicry . Further , products from the damage myocytes cause further harm to the other myocytes by T - cells.(2 ) ( 1 )
Role Of Nitric Oxide . Nitric oxide is produced by the endothelial cells . Nitric oxide has a beneficial effect on the heart as well as the blood vessels as it cause cardiac muscle relaxation and manages diastolic function . However , during the terrible inflammation , in the case of myocarditis , the expression of the inducible mannikin of nitric oxide ( iNOS ) is increased and this issue in the increased output of nitric oxide . undue production of nitric oxide increase oxidative tenseness leave in necrosis and apoptosis of myocardial cells.(2 )
Conclusion
Myocarditis caused due to viral infection through various mechanisms . This include the direct attack of the grippe virus on the muscularity cells , scathe to the muscle cells by the immune system and sphacelus and caspase-mediated cell death due to the increased concentration of nitric oxide .
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