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Neuromyelitis optica causes various serious symptoms in the patient . The condition touch on the vision as well as the motion . Patient go through pitiful imagination , depressed vision at night and visual sensation loss . Eye painis also experienced in neuromyelitis optica . The attack of neuromyelitis optica occurs due to various triggers .
How Does Neuromyelitis Optica Affect The Body?
optic symptom : As the disease affects the ocular nerves , the symptoms are related to vision . The symptom due to damage of optic face let in hurting in the eyes , hapless visual modality , difficulty seeing at night , release of vision , and motion of eye becomes difficult . The severity of optic problems is more in neuromyelitis optica as compared to normal cases of opthalmic neuritis . distinction of neuromyelitis optica from optical neuritis is done ground on the fact that in neuromyelitis optica , there is a rapid succession of ocular neuritis.1
Traverse Myelitis : Traverse myelitis is the shape takes place when the resistant organization of the physical structure attacks the spinal corduroy . The symptom related to transverse myelitis , experience by the affected role suffering from neuromyelitis optica , are dangerous as compared to symptom experienced in multiple sclerosis . The patient may experience poor bladder ascendance , painful sensation , spiritlessness and weakness in the lower extremities.2In severe case , the patient may suffer from palsy . The patient may also represent radicular pain or Lhermitte signboard .
What Triggers Neuromyelitis Optica?
Neuromyelitis optica can be spark off in the observe conditions :
Chemicals : It has been found that cocain triggers the natural event of neuromyelitis optica ; more specifically traverse myelitis in at least one affected role . The possible mechanism proposed for this phenomenon is immune sensitization and multiplication of antibody due to Bloor Brain Barrier disruption and damage of astrocytes.4
Bacterial Infection : Bacterial transmission may also trigger neuromyelitis optica attack . This is because of the reason that during infection the immune system of rules of the body is hyperactivated . Infections include ear infections , skin infections , andpneumonia.5
Viral Infection : Various viral infections such as chickenpox - shingles transmission , cytomegalovirus contagion and HIV contagion may cause neuromyelitis attack.5
inoculation : It has been found that there is a small risk of relapsing neuromyelitis optica associated with administration of vaccines.6
Cancer : Some Cancer are also known to trigger the resistant system that may lead to neuromyelitis attack.5
grounds Of Neuromyelitis Optica
Neuromyelitis optica happens when there are demyelination and firing of the optic nerve and spinal cord .
Neuromyelitis optica is an autoimmune upset . Antibodies against the boldness are imprint in the body and these antibody snipe the optic nerve and spinal corduroy . In some cases , the brain also gets impact by these antibody . In multiple sclerosis , the precise antibody has not been detect but neuromyelitis optica is the condition get by a specific type of antibody against Astrocytic Aquaporin 4 ( AQP4 ) . It is a water transfer channel found in the optic mettle and spinal cord . weewee unbalance take place because of the attack on these water channels . Demyelination hap because of the damage to oligodendrocytes.3
Another antibody that induce neuromyelitis optica is anti - MOG+ . The condition is characterized by anti - MOG associated encephalomyelitis which is an inflammatory demyelinate disease .
In some compositor’s case of neuromyelitis optica , anti - neurofascin ( anti - NF ) automobile - antibodies are also found . These antibodies affect the nodes of Ranvier in nerve cell .
Conclusion
Neuromyelitis optica solution in pain , numbness , and paralysis , specially in low extremities . The patient may also have sight problems . element that spark the flack include sure chemical substance such as cocaine , bacterial and viral transmission , cancer and vaccination .
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