Chemistry - Chemically , the conceptualisation of metaxalone is give as 5-[(3,5- ( dimethylphenoxy ) methyl]-2 - oxazolidinone with an empirical convention of C12H15N03 and molecular free weight of 221.25 .
Physical Characteristics Of Skelaxin - Metaxalone is a crystalline gunpowder . It stop no smell and is livid in colour and freely soluble in chloroform , methanol , and 96 % ethanol . It is not soluble in urine or ether . A single tablet is made up of 800 mg of metaxalone , alginic acid , B - Rose Liquid , ammonium ion calcium alginate , magnesium stearate , and clavus amylum .
How Does Skelaxin workplace – How Metaxalone act in world is still to be found . Animal research indicates Metaxalone does not act on actin - myosin complex of skeletal or smooth muscularity . Skelaxin causes central anti - anxiety sedative effects resulting in brawniness relaxation . Skelaxin does not modulate neurotransmitter at peripheral or centralnerveendings .
Recommended Dosage Of Skelaxin - The recommended dot of Metaxalone for adult and children over 12 years of age is one 800 mg tablet three to four times a day .
Absorption - Metaxalone is occupy by mucosal membrane of small intestine . The peak concentrations take place about three minute after 400 mg dose orally in fasting status after which metaxalone concentrations start decline log linearly with terminal half - life of about 9.0 ± 4.8 hr . Bioavailability and first passmetabolismbyliveris not well documented .
Skelaxin Distribution - Metaxalone has big loudness of distribution ( V / F = 800 L ) may be secondary to high lipid solubility . Metaxalone tie up to protein in plasm but the percentage of protein binding is not well defined .
Metabolism and Elimination - Metaxalone is metabolized by hepatic cytochrome 450 in liver and excrete in urine as unnamed metabolites .
Indication For Use Of Skelaxin (Metaxalone)
Inform Physician Immediately If You Have –
Drug Interaction - Skelaxin is mild to moderate sedative and mathematical function as brawniness relaxants by physiological relaxation of primal nervous System . Avoid following drugs / medications .
Skelaxin ( Metaxalone ) guard : Avoid taking Skelaxin or discuss with your physician if follow disease or illness is suspected or name . dose of Skelaxin should be adjusted or avoided if account suggests renal failure or liver nonstarter .
Activities To Avoid If Taking Skelaxin (Metaxalone) –
Drug Abuse And Dependence
Skelaxin is not abuse as addicting medications . Dependence on Skelaxin is observed for therapeutic effect and not for addiction .
Skelaxin Withdrawal
Rapid withdrawal will result in climb-down symptom .
Avoid postulate Skelaxin Or Metaxalone During Pregnancy - Skelaxin should be debar during first trimester . Consult obstetrician and neonatologist if medicinal drug withdrawal will lead in harmful consequence . Animal study has not shown any fertility stultification or abnormalities in fetus .
Avoid admit Skelaxin Or Metaxalone During Breast Feeding - It is still not try that it is secreted in human milk . As a thumb rule , breast feeding is not undertaken if a patient role is onmedicationssince many medicine are pass from the torso through human Milk River .
Skelaxin ( Metaxalone ) Use in Children - Effectiveness in children at or below 12 days of age has still not been prove .
Skelaxin (Metaxalone) Storage:
Side Effects Of Skelaxin (Metaxalone)
Central Nervous System:
Digestive:
Immune System:
Hematologic:
Hepatobiliary (Liver):
Aanaphylactoid Reactions:
Symptoms Of Less Serious Side Effects:
Symptoms Of Severe Side Effects:
Signs Of An Allergic Reaction:
Skelaxin (Metaxalone) Overdose
Contact US National Poison Hotline at ( USA ) 1 - 800 - 222 - 1222 and ( Health Canada ) 1 - 866 - 234 - 2345 .
Missed Dose Of Skelaxin (Metaxalone)
Carcinogenesis, Mutagenesis, Impairment of Fertility
The carcinogenic potential of metaxalone has not been determined .
