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Vidaza which is the trade wind name of the drug azacitidine belongs to the drug radical hypomethylating agents . It is an approved chemotherapy drug for :
How Does Vidaza Work For Myelodysplastic Syndrome?
Vidaza or azacitidine ( 5 - azacytidine ) is a pyrimidine ( one of the bases in DNA and RNA ) nucleoside analog of deoxycytidine . It has an antineoplastic activity by two mechanisms :
Hypomethylation ( modification of the DNA by the loss of the methyl radical ) of DNA ( depleted doses )
Direct cytotoxicity on the unnatural cells there in the bone inwardness by comprise into the deoxyribonucleic acid and RNA which results in cellular end . ( high-pitched doses ) . Vidaza is a ribonucleoside , so , it incorporates more into RNA than to DNA .
The cytotoxicity is impose on the rapidly dividing cells which let in cancer cells that are not responding to the normal electric cell development mechanism and the drug destroy these cells . Normally dividing cells are usually , insensitive to azacytidine therefore ; the normal healthy hematopoetic cells can be preserved .
Pharmacokinetics
Can It Cure Myelodysplastic Syndrome?
No , Vidaza or azacitidine does not cure myelodysplastic syndrome . The only possible cure for myelodysplastic syndrome is allogeneic stem cell transplanting but unluckily , most patient name with myelodysplastic syndrome are elderly mass with other comorbidities therefore , most of them are not candidates for transplant . The instauration of Vidaza is a major advance in the treatment of myelodysplastic syndrome for patients who are not suited for transplant , but it does not cure myelodysplastic syndrome . Vidaza boil down the symptom , dilute the risk of AML and improves the overall quality of biography ; it is safe and effective for elderly patients as well . subject field have shown that many patient do good and live longer with Vidaza than with formal treatment . However , only about 50 % of the patient ’s reply to the drug and from the hoi polloi respondent most of them get worse in 2 years and the termination after a relapse is very poor.(1 )
Vidaza Dosage
The dosage depend on the term and rigour . Your doctor will choose the best itinerary , dose , and frequency worthy for you . The reply is not immediate ; few cycles of Vidaza should be administered to see the response . It can be continued until patient tolerates and benefit from the drug .
Vidaza Side Effects
There are many side personal effects , some of the common side effects are :
Contraindications
Caution
Females should not get fraught while on the treatment as it can harm the babe .
Since , this drug is eradicate primarily by the renal tract , renal failure , and other renal disorders should be checked by doing a renal function test before the induction of discussion . Then , it should be monitor throughout the discussion stop as well . Especially in the elderly people drug should be adjusted accordingly .
Liver role are also check at the service line then throughout the treatment period.(1 )
Conclusion
Vidaza is the trade wind name of the drug azacitidine which belongs to the drug group hypomethylating agents . Vidaza or Azacitidine ( 5 - azacytidine ) is a pyrimidine nucleoside analogue of cytidine . It has an antitumor action by hypomethylation of desoxyribonucleic acid when given in low doses and lineal cytotoxicity on the abnormal cells present in the bone marrow by in cooperate into the DNA and RNA which result in cellular last with in high spirits does . The only potential cure for myelodysplastic syndrome is allogeneic theme cellular telephone transplantation and Vidaza does not cure myelodysplastic syndrome but it is an efficient and safe drug for myelodysplastic syndrome and its introduction is one of the major advancements in myelodysplastic syndrome discussion .
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