Usage of kombiglyze XR ( lead release ) is prohibited in case you have diabetic diabetic acidosis or severe kidney disease . It is advisable to call the MD for treatment with insulin .
Certain mass grow lactic acidosis while intake of metformin . Early sign might get worsen in form of time and this condition can be grave . Do not consume kombiglyze XR ( extend release ) and get urgent aesculapian economic aid even with soft mark like impuissance or muscular tissue pain , tum pain , sickness , breathing trouble and feeling very tired or weak .
How Effective is Kombiglyze XR?
Kombiglyze XR ( pass release ) encompasses a mixture of saxagliptin and metformin . Saxagliptin and Metformin are diabetes meds which help in control the sugar storey in the blood . Metformin efficaciously reduces the glucose or sugar generation inside the liver and reduces glucose preoccupancy by your gut . The chemical saxagliptin effectively regulates the insulin levels raise by your physical structure after having food .
Kombiglyze XR ( extended sack ) is in effect used simultaneously with use and dieting for improve blood - sugar control with type two diabetes .
Type one diabetes can not be treated with kombiglyze XR ( extended release ) .
Before Consuming Kombiglyze XR
Use of kombiglyze XR ( extend sacking ) is prohibited in case one is allergic to saxagliptin ( Onglyza ) or metformin , or if one has diabetic diabetic acidosis or severe kidney diseases . It is advisable to consult the physician for handling with insulin .
sure people get a serious problem known as lactic acidosis during consumption of metformin . This is more potential when you have kidney or liver disease , a stroke or heart onrush , congestive fondness failure , a bad infection in slip you are sixty five year or older if you are not hydrous enough or consume excess alcohol .
To ensure kombiglyze XR ( extended release ) is dependable for you , inform prior to your physician about :
You will have to temporarily stop intake of kombiglyze XR ( carry release ) if you need a surgery , any kind of CT scan or x - ray with a dye inserted into the nervure . It is significant for you inform your physician if you are planning to become pregnant or pregnant at the time of treatment as kombiglyze XR ( extend release ) could harm the unborn baby .
It is unknown that saxagliptin and metformin can harm a nursing baby or go into the knocker milk . Inform your physician if you are breast - feeding a newborn .
Anyone below 18 geezerhood of age can not use the kombiglyze XR ( exsert release ) as it is not approved .
What is the Recommended Dosage of Kombiglyze XR?
General Adult Dosage for Type 2 Diabetes:
Particularize kombiglyze XR ( extended release ) dosage ground on the current regimen of the patient , tolerability and effectiveness . In purchase order to reduce gastrointestinal side effects , steady dose titration of metformin it is advisable to have a regular dose titration of metformin .
Usual kombiglyze XR ( extended release ) dosage : by word of mouth one tab in a twenty-four hour period along with eventide food
maximum dosage : metformin 2000 milligrams saxagliptin 5 milligrams- orally one time a day
maximum dosage along with concomitant stable CYP450 3A4/5 inhibitor : metformin 1000 milligrams saxagliptin 2.5 milligrams orally one metre a day .
mortal who are not given Glucophage currently : Initial dosage metformin 500 milligrams- saxagliptin 5 milligrams by word of mouth one sentence every day .
Individuals who gets metformin as part of their current treatment plan : Initial kombiglyze XR ( carry release ) dosage : saxagliptin 5 mg plus the dosage of metformin which is being take already or the dear therapeutically appropriate dose .
What are the Side Effects of Kombiglyze XR?
It is advisable to stop intake of kombiglyze XR ( extend release ) and look up your doctor immediately if you have signs of pancreatitis : disgorgement , sickness , departure of appetite , extreme infliction in upper part of the venter that gradually spreads to your back and rapid blink of an eye .
sure the great unwashed modernise lactic acidosis during intake of Glucophage . Early signs might get worse in course of time and the term can be dangerous . Do not take kombiglyze XR ( extend release ) and get urgent aesculapian help even if you have mild side effects of kombiglyze XR ( extended release ):
Get immediate medical help if you feel any of these spartan side effects of kombiglyze XR ( extended going ):
General side effects of kombiglyze XR ( extended release ) may let in :
