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Gum Disease & Alzheimer’s: Is There a Link?
A recent field has made a startling Apocalypse about the relationship of periodontal disease or gum disease to increased risk of Alzheimer Disease . The study has boost dentists and periodontist to take good care of their teeth and gums to forbid any bacterial overgrowth . This study print in Science Advances speak about a link between a bacterium P. gingivalis seen with majority of cases of periodontitis andAlzheimer Disease . This came to light when the spinal fluid , mastermind tissue paper , and samples of saliva of Alzheimer ’s patient role and there were pregnant melody of this bacteria observed[1 ] .
The enzyme secreted by this bacterium called Gingipains was found in the brain tissue of more than 95 % of mass with Alzheimer Disease . Additionally , the study also showed that this bacterium increase the product of amyloid plaques the collection of which is associated with Alzheimer Disease . The study tested animals with periodontitis and explained how the bacteria traveled from the sass to the brain and commence to put down mentality cells[1 ] .
These findings of the study are important in that they imprint a clear connection between gum disease and increase risk of infection of Alzheimer Disease . This clause explains in detail how gum disease leads to Alzheimer Disease[1 ] .
How Gum Disease Could Lead To Alzheimer’s?
Gum Disease referred medically as periodontal disease is a common trouble which many people face . It has been linked to not only tooth loss but also increased risk of cancer . Now new study have relate this condition to Alzheimer Disease as well . The study have linked gum disease to accumulation of toxic protein in the brain which contributes to the ontogeny of Alzheimer Disease . These finding are based on testing done on mouse models that a pharmaceutical society which is research on new potential drugs for Alzheimer’s[2 ] .
All the results of the discipline done so far on this topic have been published in Science Advances . The lead scientist in this study further elaborates that many infectious federal agent have been linked to the progression and developing of Alzheimer Disease but no convincing causative element had been identified until this latest developing .
After wide enquiry , the scientists identified P. Gingivalis as the bacteria , which is the primary cause of gum tree disease , as one of the agent that importantly increased the risk of Alzheimer Disease[2 ] .
This bacteria was observed to be present in the brain of many patients diagnosed with Alzheimer Disease . Research done using mouse model unwrap that infection get by P. Gingivalis caused increase production of beta amyloid in the brain . The accumulation of beta amyloid in the brain lead to the developing of Alzheimer Disease . This is because when beta amyloid gather in the brain it forms plaque which break up normal communicating between brain cells head to their destruction[2 ] .
The toxic enzymes present in P. Gingivalis namely Gingipains along with tau and ubiquitin have been know to be colligate with development and progression of Alzheimer Disease . Once Gingipains was identified as a target , scientist started reckon for therapy go around around suppressing the effect of this toxic enzyme . They cease up with a chemical compound nominate COR388 which was regain to be most effective in suppressing the outcome of Gingipains[2 ] .
This compound also was quite efficient in reducing the comportment of the offending bacterium and lower the inflammation . The COR388 was also observe to reduce the accumulation of beta amyloid in the psyche and even protected the brain cells in the genus Hippocampus from getting damage . The scientists speak up that for the first fourth dimension now they have strong grounds that links bacterium to Alzheimer Disease and now they have the potential to falsify the onward motion of disease[2 ] .
However , despite best of efforts put on inquiry the progress has been quite sluggish . This field of study published on Science Advances has contrive some light on the link between a bacterium make gum disease and Alzheimer with an optimistic treatment scheme through COR388 . This compound is already on trial and has shown significant promise in people with Alzheimer Disease[2 ] .
Efforts are being made to play a much larger tribulation of this compound to remark its efficacy over a longer period of time in bring off Alzheimer Disease cause due to bacteria induce periodontitis[2 ] .
In conclusion , latest enquiry has clearly pointed to a link between gum disease and increase risk of Alzheimer ’s . P. Gingivalis is the offending bacterium that causes gum disease . This bacteria has toxic enzymes which increase the production genus Beta amyloid which form plaques in the wit interrupt communication between brain cells and at long last destroy them[2 ] .
After extensive inquiry , scientists have zeroed in on the bacteria P. Gingivalis and have fall up with a compound called COR388 . This chemical compound when tested on mouse model has present significant promise in not only decreasing the genus Beta amyloid in the brain but also slim down the number of the offending bacterium[2 ] .
Human trial have already pop out and have shown positive results in citizenry who have been diagnosed with Alzheimer Disease . Efforts are being made to advance further research on this topic and come up with other causative component and in force treatment strategies to divvy up with a neurodegenerative condition like Alzheimer Disease[2 ] .
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