Liver fibrosis is the inordinate scarring of liver tissue , which is due to progressive liver inflammation and liver cellular phone destruction in chronic liver disease . Liver fibrosis happens when liver prove to vivify its damaged cell through deposition of raw collagen roughage . This deposition of repaired tissue paper results in fibrous tissue formation . This magnified injury healing response interferes with normal liver function .
Causes of Liver Fibrosis
Liver fibrosis occurs due to repeated legal injury induce either by various drugs or by disorders . The hepatocytes are injured due to injury , excess alcohol consumption , toxin , hepatitis B , hepatitis C , biliary obstruction , autoimmune hepatitis , non - alcoholicfatty liver disease , andWilson ’s disease . However very seldom liver fibrosis the master job , mostly it is secondary other liver disease .
The leg determine the academic degree of damage to the liver . The bodily function or the prediction of how fibrosis is progressing is done found on a popular marking system of rules called the METAVIR scoring organisation .
The fibrosis stages roam from F0 to F4 . F0 staging depict no evidence of fibrosis , F1 stage picture portal fibrosis without any septa constitution , F2 leg depicts portal fibrosis with few septa formation , F3 stage shows various septa , but without any cirrhosis , F4 phase portray liver fibrosis . The most severe form of liver fibrosis include F3 and F4 stages .
Symptoms of Liver Fibrosis
In general , liver fibrosis is not diagnosed in the initial stages , as the symptoms do not occur until the liver damage has progressed to in advance stages . The symptom admit fatigue , phlegm , loss of appetite , nausea , puking , jaundice , mental confusedness , collection of fluid in the legs and stomach . Mostly the symptom are those of liver cirrhosis of the liver . The nous affair deteriorates due to unfitness of the damaged liver cells to strain toxic substances from the blood , which in turn work up up in the ancestry and reach the brain .
How is Liver Fibrosis Diagnosed?
It is hard to name liver fibrosis in the other leg , as there are no vindicated symptom in the rootage . The diagnosis is potential only in the later stages when the death of liver progression and symptom start out occurring . The Dr. starts by aim history of symptoms , which is adopt by a physical examination . Further , the doctor will order blood test for evaluate the function of liver , along with tests of liver enzyme ( ALT and AST ) to evaluate their stratum . The LFTs will be unnatural in the front of liver fibrosis .
Imaging Tests of Liver Are :
AbdominalUltrasoundthat expend sound waves to produce images shows the sizing and figure of the liver . It also shows the blood flow through liver . The liver with sclerosis will look lumpy and shrunken on an ultrasound ikon .
CT scanof abdomen apply special X - shaft of light imagery technology to produce multiple photo of the inside of the abdomen . The fibrosed liver will look chunky and shrivelled on CT scan .
MRI Scanproduces elaborate image of the liver by using magnetic battlefield . It is highly sensitive , can observe even belittled change , and can direct the rich percentage in liver .
Ultrasound Elastography is specifically used to notice liver fibrosis . It prove elasticity ( stiffness ) in the liver ; fibrotic liver is stiffer than a normal one .
MR Elastography ( MRE ) is a special non - invading technique as it gives detailed field of study of the liver and if used earlier , further the need of liver biopsy is ruled out . It can detect liver elasticity ( stiffness ) far more early than other imaging techniques .
Liver Biopsy is the collection of a small sample of liver tissue paper using hunky-dory needle aspiration , laparoscopic biopsy or surgical / excisional biopsy . The sampling is further sent pathologic interrogatory .
Treatment of Liver Fibrosis
The intervention of liver fibrosis is mainly diagnostic , with the aim of delaying the procession of the disease . With right care and discussion , liver fibrosis can be reversed in its initial stages as well as its progress can be slow up down .
surcease of alcohol , dietary changes , corticosteroid therapy , antivirals and anti - inflammatory drugs are used in the management of liver fibrosis .
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