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Hydroxychloroquine Treatment Option for COVID-19

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Coronavirus oft infect mammals and birds . A virus is channelise from brute to animal , animal to human , and human to homo . Thecoronaviruscauses seasonal mild to moderate upper respiratory tract infection in humans , and such coronavirus was key out SARS - CoV1 . The seasonal coronavirus contagion often diagnosed as a common coldness . The flu virus and coronavirus SARS - CoV1 make the most mutual cold and influenza - like symptoms . Every few years , life sentence - threatening coronavirus infection spreads like an epidemic contagion . A mutate coronavirus often causes such infection . In the past tense , pandemic coronavirus transmission induce by the mutate virus was named SARS , MERS , and present COVID-19 infection . COVID-19coronavirus infection is triggered by coronavirus classify as SARS - CoV2 . SARS - CoV2 and SARS - CoV1 belong to the same family of coronavirus , but SARS - CoV2 cause serious life - imperil lung disease.1

Coronavirus SARS-CoV2 (COVID-19)

Coronavirus is a individual - stranded RNA virus.2 RNA is a myopic form of ribonucleic acid . Several molecules of nucleic acid form the ribonucleic acid . Most coronaviruses are make by 26 to 32 kilobases of protein molecules . Most coronaviruses belong to to family Coronaviridae.3 Size of coronavirus is 0.07 to 0.09 micro - meter ( 70 to 90 Nanometer)2 In comparison , the bacterium are larger in diam than a computer virus . The Size of bacteria varies from 0.2 to 2 micro - meter.4 Similarly , malaria sponge are bombastic in diameter than bacteria . Size of the malaria parasite is 1 to 20 micro - meter in diameter.5

Hydroxychloroquine

Hydroxychloroquine is derived from chloroquine . Chloroquine was synthesize in 1934 by Bayer pharmaceutical society in Germany . The medication were used to cover malaria in 1945 . Hydroxychloroquine is also known as Plaquenil . Hydrochloroquin was approved in 1955 for medical use in the USA . Hydroxychloroquine is widely used as anti - malarial and anti - arthritis medication . The drug can make rare complications in patients suffering from heart disease . The side core were not abide by in patients who had no cardiac abnormalities . More than 5 million Hydrochloroquin prescription were written in 2017 in the USA for arthritis , joint pain , and prophylactic malaria treatment for traveller in the autochthonal area .

Hydroxychloroquine Treatment Option for COVID-19

The data issue on April 17 , 2020 , suggest 2.23 million people ( 0.03 % of the world universe ) endure from coronavirus , and 153,000 septic soul exit across the globe . Several clinical trials are being performed in the USA , Europe , and Asia . These trials were looking at the anti - COVID-19 gist of Plaquenil ( antimalarial ) , azithromycin ( antibiotic ) , and remdesivir ( antiviral ) medications.1There are other trials conducted to valuate the anti - COVID-19 effects of newer drug .

On April 9 , 2020 , Professor Didier Raoult from France secrete the results of a coronavirus intervention using Hydroxychloroquine and azithromycin . Treatment Study involved 1061 Patients.6 The study found 973 ( 91.7 % ) patients were cured in 10 daytime with no hospitalization , 31 patients needed hospitalisation , ten patient role were handle in ICU , and five patients died during treatment . None of the patients had cardiac toxicity . likewise , another published field of study involving 19 patient suggest Plaquenil discourse was effective in treating affected role put up from COVID-19.7

The published datum of COVID-19 intervention usinghydroxychloroquineandazithromycinwas encouraging for few treating doctor but yet not convincing to many other medico and scientist . At present several physicians across the globe have used hydroxychloroquine to care for COVID 19 infection and have report favourable results . But data published from a few restraint studies do not indicate beneficial effects . Most treating physicians preferred Plaquenil since there were no alternative anti - COVID-19 medication available to cover COVID 19 contagion . The U.S. Food and Drug Administration ( FDA ) has approved Plaquenil formalaria , lupus , andrheumatoid arthritistreatment . FDA has allowed off recording label use of hydroxychloroquine to treat COVID-19 if physician prefers the medicine and patients approve the usage of off label medication .

We all are go for presently there should one or more medication that are specific to treat COVID-19 infection . Until then , physicians and patients have a choice to consider Plaquenil or other medicine that are thought to be efficient in treating and bring down the rigor of the disease .

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