Is a Heart Infection Serious?
Infection increases the risk of cardiovascular disease , primarily because it has been relate to the arteriosclerotic process of blood vas ( it is a vascular alteration characterize by hardening , increase thickness and release of snap of the arterial walls ) affecting coronary arteries producing sharp gist infarction , and by triggering change in the conductivity of nerve impulses in the heart , which cause cardiac arrhythmia such as atrial and ventricular fibrillation . But also , the contagion of the tissues of the meat may involve the cardiac muscle ( myocarditis ) , of the valves ( endocarditis ) , and of the covering that covers the gist ( pericarditis ) .
Nowadays , cardiovascular disease go forward to be one of the main case of mortality in developed countries . induration of the arteries is an incitive disease whose genesis involves many factors , many of which are well known , such as high-pitched cholesterol levels , smoking , hypertension , ordiabetes . Among the lesser make love , however , is the infection .
Production of Atherogenesis by Microorganisms
It is well known by the scientific biotic community that in the process of formation of arteriosclerotic brass interfere resistant phenomenon dependent on both defensive cells and antibodies , and it is consider that some of these cells ( lymphocytes ) are activated by responding to a wide potpourri of antigens . These can be antigen of our own being ( autoantigens ) , but they can also be exogenic antigens such as bacteria and viruses . Although the exact chemical mechanism is still unknown , it is thought that sure microorganisms show a specific tropism by the cells of the walls of the blood vessels ( endothelial cells ) , which contributes to vascular wrong by destroying the cells ( direct cytopathic outcome ) , the inhibition of normal programmed jail cell dying ( caspase-mediated cell death ) of endothelial cells or the induction of focal autoimmune responses .
It has been found that some viruses can induce the accumulation of cholesterol crystals , or other variety of it , in the muscularity cells of the vessels , as well as favour coagulation phenomena in the mobile phone of the vessel wall .
Indirectly , during an contagion , dissimilar immunopathological process ( those acting for determine the causes of disease ) can occur that can contribute to the chronic instigative procedure in the cadre wall that spark off thearteriosclerosis . These phenomena can occur , even at a systemic level , far from where the combat injury will finally occur .
Production of Arrhythmias by Microorganisms
Cardiac arrhythmias are an authoritative cause of mortality and morbidity ; they can conduce to the worsening of other heart disease ( such as bosom failure ) , cause them on their own ( such as acuate myocardial infarction ) , or yield lesion in other organ ( such as those derived from embolisms ) . Many factors are have intercourse that favour them , such as diabetes , valvular disease or hypertension , among others . Similar to what happened with atherogenesis , the coming into court of biomarkers of ignition in patient role with cardiac arrhythmias has recently let on the possible implication , also , of infection as a initiation chemical mechanism . The primary studies have been have a bun in the oven out on atrial fibrillation , which is the most frequent arrhythmia ; also , grounds has been render in ventricular fibrillation , one of the chief causes of sudden death .
Unlike what happens in arteriosclerosis , in this cause at the instant it has only been able to show the role of a pair of bacterium that produce chronic infections and that are also involved in atherogenesis . These infections would act as initiators of the inflammatory process and would also contribute to its maintenance . Among the uncommitted subject are the findings of histological field of study of tissues , where signs of fervor are appreciated .
Despite all this , the association seems less clean than in the sheath of arteriosclerosis and more studies are still needed to elucidate whether they spiel a direct use or establish an medium divisor .
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