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Although the name could be nearly the same and turn as confusion charcot foot and Charcot Marie tooth disease are entirely different disorders . Jean Martin Charcot ’s foot is a bony deformation of the foot fall out due to sensory and autonomic neuropathy whereas charcot marie tooth disease is a hereditary sensorimotor neuropathy .
Charcot base also known as Charcot arthropathy or Charcot marijuana cigarette is a reform-minded musculoskeletal disorder get in every disease capable of make sensory or autonomic neuropathy . The most common cause of Jean Martin Charcot foot is diabetes mellitus because it can cause both sensory and autonomic neuropathy and also it is a mod epidemic of the 21st century . Other Charcot ’s of Charcot ’s pes admit infective disease likesyphilis , leprosy , etc . and non - infective disease like inebriation , spinal electric cord injury , syringomyelia , meningomyelocele , etc . are few to name.[1 ]
The symptoms of Charcot ’s human foot include the death of osseous tissue and cushy tissues overlying it at weight - bearing joints in a progressive manner and get distortion of the foot due to joint dislocation , fractures , deformity , etc . Though the accurate cause of Charcot ’s groundwork is unnamed a few combinations of theories are thought to make it .
Due to the sensory neuropathy acquired by the disease , the trauma obtain on the moved parts is unperceived and it goes on increasing due to repeated and un - healing nature . red of trophic constituent from the cutis is also responsible for it . Due to autonomic neuropathy , there is increase rake supply towards the strike area and it run to absorption of pearl , osteopenia and other bony feature . A combination of these two theory is suppose to be the cause creditworthy for Charcot ’s foot .
Charcot Marie tooth disease is an inherited disorder with autosomal predominant inheritance as its major pattern . It involves sensory and motor nerves at their fringe due to demyelination disease do by a bad factor synthesizing the myelin . Sometimes it also undergo axonal degeneracy by Wallerian degeneration followed by demyelination as go out in type 2 of the disease.[2 ]
It causes muscle wasting , bony deformities due to dour muscleman spasm , etc . Deep tendon reflexes are severely decrease or even scatty due to sensory as well as motor component intimacy . Trophic ulcers , skin breakdown , cauterise due to non - sensation , non - healing wound , etc . can be institute on the skin . It is a tardily progressing neuropathic disease which can progress till the 6th tenner after its show is usually the first decade of living .
Difference Between Charcot Foot And CMT Disease
Jean Martin Charcot foot is a very distinct and different disorder from Charcot Marie tooth disease . Jean Martin Charcot foot is an acquired disorder caused due to various local or systemic conditions causing neuropathy whereas CMT disease is a transmissible disorder inherited from the previous generation . The differences admit spar of the motor component in the former whereas the engagement of motor component is seen in the latter . CMT disease does not make autonomic neuropathy whereas it is an authoritative component seen in Charcot ’s foot . Although both diseases can present as bony deformations , non - healing ulcersCharcot’setc . but Charcot ’s foot appears as much more serious then Charcot Marie tooth disease . Also , receptive participation is a vulgar feature between the two disorders .
Conclusion
These both diseases are an entirely unlike eccentric of disorders and they differ on nearly all aspects except sensory involvement and lap of a few of the symptoms . The epithet of these disease act as confuser because of two different scientists distinguish as Charcot discover the unlike disorderliness and have been name on them .
Charcot ’s foot is an acquired disease most normally associated with diabetes mellitus whereas Charcot Marie tooth disease is linked with genetic mutation of unlike genes with an autosomal dominant type of inheritance pattern . Charcot ’s substructure is a preventable and partially curable disease with the limitation of the inherent case whereas CMT disease is incurable . Medical discussion for the systemic diseases causing , the foot is availableCharcot’sbut the same is not with the font of Charcot Marie tooth disease .
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