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The earliest symptoms of Charcot Marie Tooth disease are a weakness in the foot and leg muscles which give rise to foot and leg heftiness wasting away . There can be freakishness such as high arch , curled toes , and flat fees . They can originate trouble in walk but rarely take a wheelchair . bridge player muscle impuissance can also develop and can affect day-by-day activities such as writing , dressing up and turning doorknob . Charcot Marie Tooth disease patients also have diminish touch and temperature sensations , rarely there can be visual and hearing departure as well .
Is Charcot Marie Tooth A Form Of MS & Are They Related?
There many types of Charcot Marie Tooth disease that are categorize according to the pattern of heritage and effects on the face ( CMT1 , CMT1A CMT2 , CMT4 , and CMTX ) . Type - X Charcot - Marie - tooth disease ( CMTX ) is one eccentric of Charcot Marie Tooth disease and it ’s the 2d commonest character Charcot Marie Tooth disease and accounts for about 8 - 15 % of all CMT case . CMTX is have by a mutation in the GJB1 of the X chromosome which make a slender myelin stratum around the peripheral spunk fibers . This run to progressive nerve devolution and causes heftiness weakness and reduced sensation primarily in the feet , leg , forearms , and helping hand . Multiple sclerosis(MS ) is one of the commonest acquire inflammatory demyelinating with a preponderance transcend 1 in 1000.(1 ) ( 3 )
There have been many case sketch linking CMTX and MS and in one report which demand 70 CMTX patients three patient role ( two male patients in their 50 ’s and 60 ’s severally and a female patient 47 days ) with CMTX had feature of MS as well . These three affected role have central nervous system demyelination and fulfilled the diagnostic touchstone of MS . The exact tie between CMTX and MS is not known , much tumid studies with more subjects are require to assess it . The proposed mechanism of MS in CMTX patients is that this inherited peripheral nerve demyelination might trigger an autoimmune response against the peripheral nerve myelin sheath . A exchangeable reaction might take place in the central spunk and give rise to MS . However , it is not sure if this immune reaction come about in the peripheral cheek and then affect the fundamental nerves or if the reaction primarily occurs in the central nervous system.(2 )
Another compositor’s case field of study break a 40 - class onetime woman diagnose with MS and CMT1B , mental imagery studies sustain the diagnosis of MS and neurophysiological investigations and family account support the diagnosing if CMT1B. this study also suggests that the association can be due to an immunologic process involving TNF - alpha as the possible mechanism underlying the two disease .
Charcot Marie Tooth disease ( CMT ) is a common neurologic disease that affects about 1 in 2,500 citizenry in the US . It ’s an inherited motor and sensory peripheral neuropathy . Charcot Marie Tooth disease usually onset in other childhood or late maturity but the symptom become apparent during adolescence or former adulthood . The age of onset and severity of symptom disagree from one individual to another even in the member of the same family . Some people do not have many symptoms and they might not even know they have Charcot Marie Tooth disease but for some other people the muscle failing can be very severe and can develop life - threatening situation as well . Charcot Marie Tooth disease is not considered a calamitous disease as most people live a near - normal life , but some patients build up respiratory muscularity weakness which can increase the morbidness and mortality.(3 ) ( 4 )
Conclusion
CMTX is not a type of Multiple induration . CMTX is the 2nd commonest type of Charcot Marie Tooth disease which accounts for about 8 - 15 % of all CMT case . CMTX is do by a mutation in the X chromosome GJB1 which causes a fragile myelin layer around the peripheral nerve fibre . This run to reformist heart retrogression and cause muscle weakness and reduced genius chiefly in the feet , pegleg , forearms , and manpower . Multiple sclerosis ( MS ) is one of the commonest acquired incendiary demyelinating with a preponderance exceeding 1 in 1000 . There are many case reports of patients diagnosed with Charcot Marie Tooth disease types ( commonly CMTX ) and Multiple sclerosis . Therefore , it is believe that there can be some tie with Charcot Marie Tooth disease and MS and CMT can be a risk ingredient for the development of MS .
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