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Charcot Marie Tooth disease is a genetic disorder of the nerve that pretend 1 in 2,500 the great unwashed in the United States . People with this circumstance experience muscular tissue helplessness , especially in the arms and legs . The condition impact the peripheral nerves . These nerves are locate outside the central nervous system ( CNS ) . They hold in the muscular tissue and transmit the data point from the arm and leg to the brain so that a person can experience the touch.1

Charcot Marie Tooth is repeated muscle withering or transmitted motor and sensory neuropathy . The name come from the MD who first described it : Jean Charcot , Pierre Marie , and Howard Henry Tooth . The experimental condition is progressive , which have in mind that symptom gradually worsen over time , but most people with Charcot Marie Tooth have a normal life distich . It affect men and woman alike and all heathen groups . Charcot Marie Tooth is a congenital disease , mean it is present at birth.2

Is Charcot Marie Tooth A Serious Disease?

Charcot Marie Tooth is a transmissible disease , so people with close family members with Charcot Marie Tooth have a higher risk of arise it . The upset dissemble the peripheral nerves . A peripheral nervus consist of two major role , the axon , which is the inside of the face , and the medulla sheath , which is the protective layer around the axon .

Charcot Marie Tooth may affect the axon , myeline sheath or both , depending on the type of Charcot Marie Tooth . CMT 1 for about 1 in 3 slip . In CMT1 , mutated or bad gene cause the myelin sheath to decay . When the medulla case disappears , the axon finally becomes damage and the patient role ’s muscles receive no clear message from the mentality . This leads to muscle weakness and deprivation of sensation or numbness .

Can Charcot Marie Tooth Be Reversed?

Charcot Marie Tooth disease is a hard syndrome to contend with . The disease is by and large not lifespan - forbidding or decreased life expectancy . But in many cases , the quality of life sentence affects largely . other diagnosis and adherence to healing measure and management therapies offer better prognosis and life history quality . It is an incurable disease with symptomatic handling options providing relief and better coping ability .

The condition is cause by one or more bad genes . In most cases , you inherit the faulty cistron from one or both parents . The defect intervene with the use and structure of your peripheral nerve sheath and axons . These are the insulating layer around your nerves .

In some rare guinea pig , people are spontaneously born with Charcot Marie Tooth without inheriting a bad gene from their parents . There are five main type of Charcot Marie Tooth , and each has its own cause3 :

Charcot Marie Tooth 1 is often get by a duplicate of a factor on chromosome 17 . This gene controls the yield of the protective medulla sheath of your nerves . CMT1 is also get by other genetical defects .

Charcot Marie Tooth 2 results from a defect in the axone of your peripheral nerve cells . This is cause by a defect in your mitofusin 2 gene .

Charcot Marie Tooth 3 , also squall Dejerine - Sottas disease , is because of a mutation in your P0 or PMP-22 factor . This type of CMT is rare .

Charcot Marie Tooth 4 is because of multiple gene mutant . These genes include GDAP1 , MTMR13 , MTMR2 , SH3TC2 , NDG1 , EGR2 , PRX , FDG4 and FIG4 .

Charcot Marie Tooth X is make by a point mutation in the connexin 32 protein on your ex chromosome .

CMT1 is the most common case of CMT . All types of Charcot Marie Tooth weaken the signaling that journey from nerve in your extremities to your brain .

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