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Is Charcot Marie Tooth Disease Painful?

Charcot marie tooth disease can deliver as muscle wasting , atrophy , trophic ulcer , non - healing lesion , bony deformities , etc . human foot cavus is the most commonly associated bone deformity found in Charcot Marie tooth disease . These can head to the experience of pain which could be of two types , the strong-arm annoyance , and the neuropathic pain sensation .

The strong-arm pain results from the ulcers and superadded infections , bony misshapenness , etc . Neuropathic pain occurs due to the legal injury of nerve fibre specially belonging to sensory nerves which can be demyelinating or axonal degeneration in case of Charcot Marie tooth disease . The neuropathic pain can be sometimes perceived as phantom pain due to the damage cheek endings sending nervous impulse to the pathway without a physical symptom .

To relieve physical pain , the mathematical group of non - steroidal anti - inflammatory drugs is the drug of choice . These have anti - inflammatory , antipyretic and analgesic action at law which not only let off the pain sensation but also improve the systemic symptom . It decreases the deduction of prostaglandin in the organic structure in response to inflammation by inhibiting the Cox enzyme creditworthy for the product of prostaglandins . Antibiotic group of drug can also be order by the doctor to prevent the superadded infections on the already present ulcers .

For relieve the neuropathic pain there are many groups of drugs which can be used effectively . item-by-item therapy is consider because the employment and efficacy of the drug look upon each patient ’s metabolism . Tricyclic antidepressants such asamitriptyline , nortriptyline , dothiepin , amoxapine , etc are the most usually used drug in neuropathic pain . Another group of drugs include antiepileptic drug like pregabalin , Neurontin and opioid analgesics like morphia , etc . can be used in severe eccentric of neuropathic pain in Charcot Marie tooth disease . cardinal brawn relaxant and neuromuscular inhibitors like botulinum , baclofen , etc . can also be used.(1 )

Can CMT Skip A Generation?

Charcot Marie tooth disease follows an autosomal prevailing type of inheritance radiation diagram for the extension of the disease to successive generations . case 1 and type 2 belong to this class and are set up in the sequential multiplication with a probability of about 50 to 75 % depending upon the dominant alleles present if anyone parent is suffering from the disease . If both the parent her lose from the disease , the chances of generation of disease drift from 75 to 100 % and also increase the severity of the disease in the offsprings .

But it is potential that the Charcot Marie tooth disease can bound off a generation without affect any of the offspring and then present again in the subsequent generations . Type 3 and type 4 along with some subtypes of type 1 and type 2 be an autosomal recessive case of hereditary pattern pattern . In this inheritance , the disease propagation is not found in successive generations at every trice and occurs more likely if both the parents are affected with the disease . The accumulation of two recessive alleles is necessary to induce disease in this pattern which could lessen the probability of transmission and after one generation the soul marrying with another mortal carrying recessive allele can lead to transmission of disease in the next genesis . Few suit of hug drug - colligate recessionary heritage rule are also found in subtypes of character 1 and type 2 Charcot Marie tooth diseases.(1 )

Conclusion

Charcot Marie tooth disease is a sensorimotor neuropathy present itself in the first decade and continuing for a lifetime due to its slow progression and incurable nature . It is a painful condition with physical and neuropathic painfulness as its constituent . Only symptomatic discourse for the pain can be give with the service of medications and sometimes surgical interventions .

It is quite possible that Charcot Marie tooth disease can also skip a propagation like in case of only one parent affected with the disease with a exclusive prevailing allele marrying with the unaffected someone . Autosomal recessive and x - link recessionary inheritance patterns are also seen in few subtypes and are chiefly responsible for the character seen with skipping of generations without suffering from the disease .

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