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Multiple sclerosis , a inveterate debilitating disease triggered by damage to the myeline sheath of nerves in central nervous organization ( brain , spinal corduroy and optic nerve ) . This progressive autoimmune disease leads to inflammation and pock of nerve sheath roughage at multiple levels in the central nervous organization causing exposure of nerve fibers . The leave boldness impulse conduction abnormality is responsible for all the varied symptomatology in multiple sclerosis .
The symptom of multiple sclerosis are diverse and each case in unique . The various presenting symptoms include , tiredness , spiritlessness , muscle spasms , prickling , pain , seizures , vision problems , headache , cognitive dysfunction , spoken communication problem , external respiration problems , dysphagia , dizziness , Great Depression , bladder disfunction , bowel changes , see problems , musclespasticity , tremorsand reduced sexuality drive . Although , not all the symptom will be present in a patient , some symptoms will be aggravate and some of the symptom might be absent .
Is Itching A Sign Of MS?
In general , itching or pruritus is relate with allergy , drug chemical reaction or tissue paper infection take care in systemic diseases ; however , in multiple sclerosis itching is neurological in nature . Although , itching is present in multiple sclerosis , it is a uncommon star sign . When present in MS , it is a form of dysesthesia . Dysesthesia is any type of abnormal sensation found in patient of MS , which admit cut , stabbing , stick and acerate leaf , electric , prickling or deplume nuisance .
Pruritus when found in multiple sclerosis , is mostly paroxysmal in nature , mostly occurring at night , often arouse patients from their sleep . Pruritus in MS is consistent with other paroxysmal approach , such as of seizures , which also last between several bit to minutes .
late study have picture that itching in patients is usually sudden and abrupt in origin ; the duration is usually short lived and last for several sec to minutes . itch is not persistent and in nature and fret the domain has no effect on itching . Itching is unremarkably felt about five to six time a Clarence Shepard Day Jr. and sometimes even more . The fire of itching is felt symmetrically and segmentally on face , trunk and/or extremities . The itchiness is mostly associated with painful sensation sensations and may either follow pain or come before pain sensations in that particular area .
Although , pruritus is ascertain in MS , it is not clear-cut as to the precise cause of it . There have been various theory around this and what can be considered consistent here is that these paroxysmal pruritus attacks are set off by movement or some sort of sensory stimuli .
Pruritus can of a sudden take place when there is bm of branch or while walking . It is a well shew fact that MS is aggravate by heat , so when temperature is elevated by 0.5 - 1.0 degree Celsius at night , these paraoxysmal attacks of pruritus normally occur . Heat is make out to farm itch ; however , the itching in MS is not generalise , it is localized to particular tegument areas .
Research has sustain close relation between pain and itchiness in MS patient as they have noted that pain and itching have been present in the same localized area . It is also note that cytosine character are associated with itch and electrocution and delay pain . input with low-pitched frequency body process is associated with itching , whereas , stimuli with high frequency activeness has been consociate with burning and delayed pain . Thus , there exists a confining relation between pain and itching .
Pruritus in MS is not associated with any kind of allergy so regular medication for itch or allergy , such as Cortone Acetate , Benadryl or anti - histamine are not effective to verify this sensation . MS related itch is neither better by scratch . Since , the itching is affiliate with abnormality in nervus conduction and has neurogenic origin , medications place nerve impulses are only effective for them .
Carbamazepine , which is anti - epileptic or anti - convulsant , is found to be in effect in controlling pruritus colligate with MS . In addition , carbamazepine is also used to relieve certain cheek botheration , including that of trigeminal neuralgy . This further , bear out the hypothesis that hurting is closely consort with itching in MS .
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