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Multiple organisation atrophy is a rare neurogenerative disease1 , the exact etiology and the pathogenesis of the disease is unknown and many believes it is sporadic and some say it is inherit , it is an infectious disease and can be convey to other the great unwashed , some say it is due to autoimmunity , some study say trauma can lead up multiple system wasting away , and some studies say pesticides can be a cause but none of these theory are proved with tolerable grounds . Therefore , the precise cause is not know however , it is believed that the cause can be multifactorial and genes , environmental factors and lifestyle factor can all put up it to the manifestation of the disease . Many studies are ongoing to find the cause of this debilitating and fatal disease and still there has not been an precise cause find out with right grounds and proof .
Is Multiple System Atrophy Contagious?
There is not much grounds useable to prove if multiple system of rules withering is contagious or not.2There was an article released by University of California – San Francesco in 2015 on “ Multiple System Atrophy ( Prion ) may be contagious , resemble Parkinson ’s disease – A danger to Clinicians ” says that MSA is a Modern eccentric of prion disease . prion are normally found in the human brains however , the exact function of it is unknown . Abnormal prions happen from an unnatural fold of the normal cellular protein prion . This abnormal fold of the prion causes rapidly reformist brain damage which is fatal and neurodegenerative disease is one type of brain damage .
This article was put out on experiments done in Prusiner ’s lab in 2013 , brainiac tissue paper from dead multiple organisation atrophy patients have been taken and the mice were give away to it and the mouse developed neurodegeneration . The brain of the infect mice had high levels of human alpha - synuclein ( in all eccentric of multiple system wasting away clumps of unnatural alpha - synuclein protein is found in many parts of the brain andspinal cord ) and the septic mice brain tissue channel the disease to other mouse as well . The subject area stress that wellness care providers , laboratory faculty and citizenry doing research sketch on multiple system atrophy patients should take superfluous care when dealing with an multiple scheme atrophy patient role as most neurodegenerative disease can be due to prion disease and it can be contagious .
Then in 2018 , the above - refer article was reviewed by a group of professional person and they concluded that there is not adequate evidence to test about the infective nature of α - synuclein aggregates in humans . The transmission of misfolded α - synuclein was reported primarily in animal manakin and there has not been any evidence about multiple system atrophy transmitting from one affected role to another . Therefore , they suggest that patients should be assure that multiple organization withering is not transmissible or transmitted from one person to another even with close impinging . They also suggested that standard precautions should be aim by citizenry manage multiple system atrophy patients ’ brains and other tissues . Also , the equipment used for multiple organization atrophy patient should be thoroughly disinfect . Further written report are postulate to prove the transmissibility of the α - synuclein2and how precisely it circularize so as to confirm that multiple organization atrophy is contagious . They have told that multiple system atrophy is not catching and patients , caregivers , and health care professionals should not worry on the infectivity of multiple system withering as there is no right evidence to rise it . Also , the fact close contact with multiple system of rules atrophy patients does not put anyone at risk of getting multiple system atrophy .
Conclusion
The accurate etiology and pathogenesis of multiple system wasting are not known . There are many proposed theory but none of them have been prove with enough grounds . There was an article released by the University of California – San Francesco in 2015 on experiments done in Prusiner ’s lab in 2013 . They believe that multiple system atrophy is a unexampled type of prion disease as mouse got neurodegeneration when they were endanger to mental capacity tissue paper from dead multiple system withering patients . The brains of the infect mouse had in high spirits levels of human alpha - synuclein and the infected mice brain tissue channelise the disease to other black eye as well . However , this clause was reviewed by some professionals in 2018 and they close that there is not adequate evidence to establish about the infective nature of multiple organization atrophy and it is not contagious as there is no proper evidence.2
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