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A nickel allergic reaction is an allergic reaction because of liaison with Ni - arrest substances , a so - called contact allergic reaction . It can also happen when you ingest food containing Ni . Nickel ranks first worldwide in the hit leaning of physical contact allergens ( a cause of allergic reaction ) . The allergy to Ni is particularly vulgar among hairdresser . Women are more susceptible to nickel allergy than man with 0.8 to 5.9 % of men are bear on in the population , but around 11 % of women are affect . nickel note allergic reaction is more common in people under the age of 30 years.1
Is There Nickel In Titanium Implants?
Titanium implant are usually devoid of nickel . However , sometimes atomic number 28 - titanium alloys are used . Nickel deposits in biocompatible titanium implants may also cause nickel note allergic reaction and subsequent sensitized reactions.4,5
Is Nickel Toxic?
For individuals with no nickel allergy , the metal is toxic only when ingest in large amount ( more than 500 magnesium ) . But , to an allergic person , a low social disease may trigger serious supersensitive conditions . atomic number 28 is more toxic when inhale through the air travel . Some compound of Ni such as Ni carbonyl get severe toxicity when inhaled . Inhalation of Ni can be carcinogenic as well.6
The most common form of nickel allergic reaction is in the form of eczema at the point of contact with itching , redness and watery blisters . With increase sensitivity , eczema can also occur on more distant areas of the tegument , for lesson , in the axilla or on the face , and in particularly severe cases all over the skin . In citizenry with high sensitiveness to Ni , eating nickel - check food can triggereczemathat affects the full body part , specially the eyelids , elbows , neck , and hands . Also , ear canal eczema , head itch , tomentum release , joint pain , migraineandfatigueare possible.2
Skin test , drinking mental test , and so - called speckle psychometric test are used for the diagnosis . Especially common is the dimethylglyoxime tryout . In this case , the suspect object is dipped in a root with dimethylglyoxime and then some of the solutions are applied to the skin . If the affected skin country register an hypersensitized reaction within 72 hours , this will realize the suspiciousness of a nickel allergy.3
Nickel Is An Important Trace Element In Our Body
Nickel is present in the main in the pelt , in the pearl marrow and in various enzyme . In addition , scientist have found that nickel and smoothing iron concentrations in the human consistency are closely linked . However , all these atomic number 28 does not trip an allergic reaction . A requirement for an allergy is long - terminus hide contact with nickel and a hereditary sensitivity to allergies , while the nickel allergic reaction it is not inherit . the great unwashed with atopic dermatitis seem to be specially vulnerable to the atomic number 28 allergy . It has become unmortgaged that there are binding web site for nickel in the immune system itself , which trigger an immune reaction . This explains why one can be supersensitised to atomic number 28 , but not to other metals .
The Nickel Allergy Is Triggered By Nickel Ions
These are the smallest nickel speck that can be release from nickel - containing object during prolonged skin contact . These nickel ions penetrate the skin and can alert the immune system to masses who are prostrate to allergies . It afterwards forms antibodies against the intruder . Renewed middleman then spark sensitized symptoms . This does not have to be done through the tegument ; even the inhalation of atomic number 28 - contain smoke ( cigarettes ) or the economic consumption of nickel - incorporate food can cause allergic symptoms .
Often the smallest amounts of nickel are sufficient . The reflection often happens in childhood , especially in girls who are adorned early with a necklace or stud earring . Since 1993 , however , allergic reaction to young girl has been on the decline.2
Inflammation Promotes The Development Of Nickel Allergy
Inflammation of the skin in the area of atomic number 28 contact has an effect on the development of atomic number 28 allergic reaction . So , piercing of earlobes ( and other country of the body , such as the nose , naval , etc . ) with nickel - containing pins and then attaching nickel - containing jewellery in the wound area very often leads to Ni allergies.2
Conclusion
Exposure to nickel through peel liaison can cause tangency allergy to sure individual who are sensitive to nickel . The most common form of nickel allergic reaction is usually in the course of eczema at the point of contact with itching , redness and watery blisters . Skin tests , drink tests , and so - called patch tests are used for the diagnosing . Ni down payment in biocompatible Ti implants may also cause nickel allergic reaction . Nickel is toxic only when squander in mellow DoS for non - hypersensitized somebody . But inhalation of nickel - containing compounds can pose serious wellness risks . People with a Ni allergic reaction should avoid contact or ingestion of nickel even in a small amount .
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