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Merkel Cell Carcinoma Vs. Squamous Cell Carcinoma
Merkel cells are receptors formed of neuroendocrine cells which are connected by nerve endings and these take the sensation of touch and vibration to the brain and are located in the epidermis[1 ] .
Squamous cadre are flat cells of epithelial descent shape the outmost and upmost level of cutis and even cuticle . These are keratin hold cells which perform the function of protecting the eubstance against injury and abrasions by maintaining its continuity .
The unexclusive gigantism of both the cells due to various factors leads to their respective cancers . Squamous cell Crab are much more common than Merkel prison cell cancer . Squamous cell carcinoma create 20 % of the full skin cancers of non - melanomatous descent whereas , on the other hand , the Merkel cell cancer is quite rare cancer to be found alone[2 ] . It is associated with other skin cancers and find oneself in multiple Crab syndrome of cutis .
These cancers dissent very much in their presentation and polarity . Merkel cell carcinoma usually presents as nodule of belittled size on the tegument especially of head and neck regions with a holding of changing colors like blue , purple , red , etc . whereas squamous cell carcinoma acquaint as a shallow ulcerative wound with elevated tolerance and presence of plaques marks its conformation .
The factors responsible for for both cancers are most the same . Prolonged exposure to the sunlight , in particular , the ultraviolet light rays is the risk and etiologic factor for the skin Cancer . Very high - level exposure to the sunlight for long periods can run to squamous cubicle carcinoma but on the other mitt , low - intensiveness exposure of , for foresighted menstruation can head to Merkel cellular telephone carcinoma . The UV re can head to mutations in the genetics of the hide cadre and the unremarkably meet factor to be mutated is the Tp53 gene . It is a tumor suppressor cistron and its curtailment can go to stimulation of transforming gene which are responsible for for reducing the cell death .
Various immune system defects like unfitness to do DNA resort in the peel cells known as xeroderma pigmentosum can also go to accumulation of the mutations in the cell which can trigger off the squamous cell carcinoma far more often than Merkel cell carcinoma which is relatively very rarefied with it .
Exposure to the ionizing radiation such as X re , Gamma ray , etc . can easily propel these mutations in the cells and it could conduct to cancerous growth . Immunosuppression is also an etiologic broker for the triggering of the skin cancer . Since there is more of the relative incidence of squamous electric cell carcinoma than the Merkel cell carcinoma , these factors are found commonly associated with squamous cell cancers .
Both the Crab have their treatment of choice is surgical resection of the lesion but the wound of squamous carcinoma requires more margin to be resect due to ulcerative presentation whereas Merkel prison cell carcinoma is tie in more often with lymph node dissection due to higher metastatic pace . Moh ’s microsurgery is do in both cancers .
Although both can be metastatic in nature but Merkel jail cell cancer is more metastatic and is associated with a poorer forecast than the squamous carcinoma . The chances of treatment and natural selection are more in squamous prison cell carcinoma .
Conclusion
The squamous electric cell cancers are having a much large number of face than Merkel cell Cancer the Crab because of the strong association with etiological factors . Merkel cell carcinoma is report in less number than squamous cellphone carcinoma because of the difference in presentation . Merkel cellular phone carcinoma looks like a tubercle on intro which is lesser threatening to a common human race whereas squamous cell carcinoma presents as an ulcerative wound which appears far more dangerous and menace to cause patients to report early and more frequently . It is crucial to know that both are lethal and both are to be describe . No tubercle or ulcer is to be taken lightly because of their looks since these could become more than bothersome for the affected role .
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