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Depression is a mental health disorder that is typically characterise by having a persistently down mood , a passing of interest in activities that were once enjoyable , and consume an overwhelming feeling of sadness at all times(1 ) . If you have been diagnosed with major depressive disorder , then fortune are high that your doctor has put you on at least one major antidepressant drug . With the advances in the medicament , there have been many new drug and aesculapian therapies that are being used for treatment of imprint . Combination drug therapy is one such innovative intervention plan that many psychiatrists and doctors are increasingly using in recent days . Using combining therapies for depression treatment has become a pop solution for medical expert today and we take a look at how combining therapies mould , what it entails and whether or not it helps in the treatment of depression .
Combination Therapies For Depression
Some of the departure character of therapy and medications used in combination drug therapy for depression are discussed below .
Antidepressant Medications for Treating Depression
Until the last duet of days , Dr. used to dictate only one major antidepressant medication from a single form of drugs , at one full point in prison term . This process is known as monotherapy . If that specific prescribed drug failed to provide any relief , then the doctors would opt for trying another medication , either from within that socio-economic class of drugs itself or they may switch over to another social class of antidepressants also .
enquiry has now shown that lease antidepressant drug from unlike classes of antidepressants is the best way for treat major depressive disorder ( MDD)(2 ) . A study published in The American Journal of Psychiatry in March 2010 found that the use of a compounding antidepressant coming at the very first sign of MDD doubles the likeliness of absolution .
Using Atypical Antidepressant Medications for Depression
There may be sure medicine that , when used in conjunction with other medicine , work on wonders in treating difficult - to - treat to grievous levels of depression . For example , when used on its own , the medicament bupropion is known to be quite effective at treating MDD . However , when used in alignment with other medications , it may knuckle under even estimable solvent , especially in treating severe level of imprint . Bupropion is , in fact , one of the most ordinarily used antidepressants in combination therapy medication . Bupropion is also used unremarkably with 5-hydroxytryptamine - norepinephrine reuptake inhibitors ( SNRIs ) and selective serotonin reuptake inhibitors ( SSRIs).Bupropion is also one such medicinal drug that in general well tolerated by most people who have earlier experienced the severe side gist of other antidepressant medications . Bupropion is also known to allow for succour in the sexual side effect that are ordinarily associated with SNRIs and SSRIs , such as a decreased libido and anorgasmia(3 ) .
Mirtazapine is also another unspoiled option to be used by people who are experiencing a loss of appetency and also suffering from insomnia due to MDD . However , the most common side effect of mirtazapine is sedation andweight gain(4 ) . Mirtazapine also has not been studied as comprehensively for use as a combination medicament as bupropion has been .
Atypical Antipsychotics for Treating Depression
Research studies have also show that patients suffer from MDD may benefit in some of the residual symptom by taking SSRI combined with atypical neuroleptic drug . medication such as aripiprazole can be used in combination with SSRI , though there are sure side effect associated with these medicine , admit muscletremors , metabolic disturbance and weighting gain . This is why atypical antipsychotics have to be considered carefully before being used in combination therapies since they may very well prolong or worsen some of the symptoms of depression .
L-Triiodothyronine (T3)
Many Dr. also use L - Triiodothyronine ( T3 ) , which is a thyroid hormone , in combination therapy with monoamine oxidase inhibitors ( MAOIs ) and tricyclic antidepressant ( TCAs ) . Studies have shown that T3 is better at supercharge the consistency ’s response to depressive disorder treatment , as compare to increase the chances of entering remission(5 ) .
Using Stimulants for Depression
Methylphenidate ( Ritalin ) and D - pep pill ( Dexedrine ) are the stimulation that are being used in the treatment of depression . These stimulant can also be used as monotherapy ; however , they are also being used as part of combination therapy for depression along with antidepressant medications . stimulus have been proven to be most beneficial when doctors are look for a immediate reply from the patients . Patients who also have comorbid weather such as a inveterate medical sickness or a apoplexy , or those who are debilitated , make for good candidates for this combining therapy with stimulant drug .
Using Combination Therapy as the First Line of Treatment in Major Depressive Disorder (MDD)
Monotherapy treatments have been found to have a relatively low rate of success , which is why many Doctor and genial health expert consider that using combination therapies as the first approach to treating MDD is the in force solution available(6 ) . Nevertheless , most physician still begin the treatment with the use of a individual antidepressant medication itself .
If you have been put on combining therapy for treat natural depression , then you need to give it some time to work . Usually , two to four weeks is deliberate to be the trial full point for any new medicament for depression . If during this stop , you do not show any adequate reaction , then your Dr. may change a medicament or add some extra medicament to shift the combining for good treatment of depressive disorder . It may take some trials before you hit upon a intervention plan for depression that succeeds .
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