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It is a hereditary disorder which means it can be inherit from one ’s parent with their transmissible material . The patients get from this disease should be well known to the inheritance pattern of it . It follows the autosomal dominant eccentric of heritage in most of the cases . In this character of hereditary pattern , the patient suffer from the disease can transmit mutate genes in the next generation in 50 % of the offsprings if only one dominant allelomorph is present and can transmit the disease to 75 % of the young if both the dominant alleles are present . Similarly , if both parents are suffering from this order then there are probability of 75 % to 100 % transferee of the disease in the offspring depending upon the act of prevailing allelomorph present in them.[1 ]
What Are The Ways To Prevent Charcot Marie Tooth Disease?
So for good bar of the Charcot Marie tooth disease , it is very important for the affected patients to forfend cognate spousal relationship that is marriage within their own family of roue relatives . Two patient suffering from this disease should not marry each other because the chances of disease inheritance are very gamy in such example with both affected parent than as compare to the cases with one parent affected .
Appropriate genic counseling with the service of a genetic counsellor is necessary to prevent the disease from occurring in the offsprings . Risk understanding about the heritage of the disease must be done to properly design the nestling who is disease - innocent . antenatal testing of the foetal chromosomes could be done in cases of some type of inheritance to detect the mutated genes in it and the couple can make the determination for keep or abort the fetus . Beforehand hereditary testing of the couple could be done to find the defective genes in them so that the appropriate advice could be yield to them about the preparation of baby .
Charcot Marie tooth disease is an incurable disease and despite various researches , no effective treatment has been found till date for it . The Wallerian degeneration and demyelination is a non - treatable case of pathology because the chemical mechanism to redevelop the myelin sheath or the axons has not been found yet . A few of the latest researches have shown promise in this field with a target on the myelin metabolism processes and supplementation of lipid fabric for its maturation but these are in their initial phase only.[2 ]
Does Charcot Marie Tooth Disease Reoccur?
Since it is an incurable disease , the enquiry of return does not move up . Because return pass off only after the disease undergoes remitment adopt by accomplished cure which is not seen in the case of Charcot Marie tooth disease . Even relapse of the disease can not be defined because it is a progressive disease and no drug or treatment has been detect which could slow the progression of this disease .
diagnostic handling of the disease based upon the different difficulties meet by the patient is done to ameliorate the quality of life of the patient . Various operative modalities are available to compensate the deformity suffered in this disease .
Conclusion
Charcot Marie tooth disease is a ancestral disease with an autosomal dominant character of form of inheritance . It is very much helpful for the patients suffering from this disease to understand the heritage patterns because this will not only aid them to carefully select their union partner but also will prevent the disease from propagating in the future offsprings . Genetic counseling is the full method acting for prevention of such heritable diseases . The help of a genetic advocate could be sought and right advice should be taken from them .
There has been no treatment found till day of the month which could either heal or slow down the progression of Charcot Marie tooth disease . Various enquiry project and animal study are pass away on to find the technique of myelin regeneration and development so that various otherdemyelinatingdisorders can also be cured along with this disease .
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