What is the Best Medicine for Glaucoma?
Prostaglandin analog , a newfangled group of ocular hypotensive drug are the best practice of medicine for treatment of glaucoma . Latanoprost and unoprostone are the two most wide explore prostaglandin drug , still in effect in utilisation . Both these anti - glaucoma drug have proven to be safe for patient and very fewer casing of mild side effects have been recorded . Latanoprost was first introduced in the year 1996 in the US and Europe . Its mechanism is unproblematic and different from other drugs . It fall the intraocular pressure and increases the uveo - scleral outflow . Prostaglandins broadly speaking work by soothe musculus in the eye ’s interior structure to allow good outflow of fluid , thus reducing the buildup of center pressure . One of the major advantages of this latanoprost is one - prison term role in a day ( 50 μg / ml ) can effectively reduce 30 % of the intraocular pressure in glaucoma affected role within a calendar month .
Latanoprost
Latanoprost is also useable with other drug as combined which is more effective for glaucoma . Carbonic anhydrase inhibitors , genus Beta - receptor antagonist , sympathomimetic agonists , and cholinergic agonist are some of the other drug available in combining word form . It was once introduced as a 2d - telephone circuit of the drug but it is now extensively used as primary therapy for the various cause of glaucoma . Iris pigmentation and cystoid macular edema have been reported as an adverse impression but very low absolute frequency .
Unoprostone
Unoprostone , is the top FDA okay topical prostaglandin analog after latanoprost , which is used widely in Japan . It has intraocular insistence lowering effects and it is used in 1.2 mg / ml twice daily . It in effect reduces 15 % of the disease within two to four hebdomad . prostaglandin are prescribed for all forms of open - angle glaucoma , include primary assailable slant glaucoma , pseudoexfoliation glaucoma , pigmentary glaucoma , and normal - latent hostility glaucoma . These drug are not effective in primary congenital glaucoma and slant closure glaucoma . Travoprost and bimatoprost are recently developed prostaglandin drugs wide used in the USA .
Xalatan
Xalatan ( stain name for Latanoprost ) most widely sell drug in westerly countries . It is available as generic medicine , work efficaciously within 4 60 minutes and last up to remainder of the day . It has less stability and hence trade in 2.5 cubic centimetre measure . Its use in pregnant precondition is limit due to high natural event of miscarriage in cleaning lady . FDA classified latanoprost as “ degree centigrade ” category peril constituent . Blurry vision , redness of the eye , itch , and darken of the iris are vulgar side gist of latanoprost . Unoprostone was commercialise under the trade name Rescula for the management of open - angle glaucoma and ocular high blood pressure , but is now discontinued in the US . Travoprost sell under brand name of Travatan , Travatan Z and generic version of Travatan Z has been approve by the FDA .
Researcher counsel that wiping the spare fluid near the eye can result in loss of eyelashes . So contact of eyelash with absorptive cotton wool must be avoided . Bimatoprost sold under stigma name Lumigan used for the discussion of open - angle glaucoma and opthalmic hypertension in adult patients . It is either alone or in compounding with a beta blocker typically timolol . Tafluprost ( sell under zioptan ) is a prodrug of the combat-ready substance , tafluprost pane , a structural and functional analogue of prostaglandin F2α . The most unwashed side effect is conjunctival hyperemia , which come about in 4 to 20 % of patient .
All prostaglandin analogs should not be used with touch lenses and must be removed before instilling the drug . After 20 minutes , the lens can be reinserted . Prostaglandin analogs can be used in conjunction with other middle drops or drugs but the experts propose that it has to be used as separate drop i.e. lot at least 5 minute later on .
Available combination for glaucoma therapy in the US include Dorzolamide / Timolol , Brimonidine / Timolol , and Brinzolamide / Brimonidine . Additional well - brook combination drops are usable outside the US but are not FDA approved . The biggest drawback for patient prescribe combination medication is the in high spirits cost .
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