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Neurofibroma is a tumor take shape from the multiplication of neuronic or perineural tissue paper . It is a benign tumour normally presenting on the skin in the form of tubercle or extrusion . It is soft in consistency and can be contract by fingers . The reason for the soft consistency of the neurofibroma is the absence seizure of the collagen in the dermis stratum of the skin . On compression , there is no resistance feel under the neoplasm which is key out as analogous to a button hole hence neurofibromas are sometimes referred to as buttonhole sign .
Neurofibromatosis is a hereditary syndrome occurring due to genetic defects and present as cutaneous , nervous , and skeletal system mental defectiveness . Neurofibromas can develop in this syndrome but are not compulsory to be found in it . There are other cutaneal features in neurofibromatosis like cafe au lait macules , axillary freckling , hyperpigmented patches[1 ] , etc . The coffee shop au lait macule are characteristic of the neurofibromatosis syndrome . These macules can have a smooth border or rough molding . Smooth butt on macula are known as the coast of California whereas more or less abut macules are known as the seacoast of Maine .
The aflutter system involvements admit various tumors like optical glioma , neurofibromas , vestibular schwannomas , etc . Optic glioma and neurofibromas are usually associated with neurofibromatosis character 1 whereas vestibular schwannomas are commonly associate with neurofibromatosis type 2 . Spinal corduroy tumors are also associate in a few cases where they are concern to as dumbbell - shaped tumors because of their specific shape seen[2 ] .
emaciated system abnormalities found in von Recklinghausen’s disease areosteoporosis , scoliosis , multiple fractures , osteopenia , os dysplasia , pathological joint fusions , etc . The commonly affected finger cymbals are the farsighted off-white like thighbone , humerus , tibia toetc .
Since von Recklinghausen’s disease is a collagen upset there are various vascular abnormality also associated with it . Vascular stenosis and high blood pressure are seen consistently in cases of neurofibromatosis . These may also be the presenting feature of it as a clinical casing which could be diagnosed after complete soundbox interrogatory .
Difference Between Neurofibroma And Neurofibromatosis
Usually , the neurofibromas are of benign origination with minimum symptom and occur singularly without any correlation with other systemic symptoms whereas von Recklinghausen’s disease occurs with a group of symptoms one of which can be the formation of neurofibromas . These neurofibromas occur at various sites haphazardly and are multiple in numbers link up with other cutaneous symptom like hyperpigmented macula etc .
Neurofibromas , when fall out singly without any syndromic association , are easy to treat with no malignant translation seen among them in maximum cases . But in cases associated with neurofibromatosis , the neurofibroma can undergo malignant change or can involve multiple nerves or nerve bundles to work plexiform neurofibroma which is unmanageable to treat and is also having a detrimental effect on the calibre of liveliness .
The loss of the skin sensations , autonomic symptoms etc . is minimum with the neurilemoma whereas these problems are increased in case of syndromic association with neurofibromatosis . Neurofibromatosis is also associate with high blood pressure symptom due to vessel involvement which is not seen in the sheath of neurofibroma .
Neurofibroma alone can be treated via laser treatment easily without complication whereas neurofibromatosis has its predominant treatment as in cast of surgical treatment although in many slip of neurofibroma also , the surgical resection is done in absence seizure of laser therapy . The operative treatment of the neurofibroma direct to less scarring and no recurrence in funny neurilemoma tumour . The surgical resection is more star to more scarring and high recurrence rate in neurofibromatosis associated tumors .
Conclusion
Neurofibromas are a nerve affect tumor which could pass off as a single identity or can also pass off in association with other symptom in hereditary disorders like von Recklinghausen’s disease . Neurofibroma , being a benign tumor is a less dangerous and treatable disease whereas von Recklinghausen’s disease is more dangerous because of the possibility of malignity as well as multiple organ and organ system involvement in it . As these two disease identity can make confusion amongst them , therefore double-dyed limit is necessary between the guinea pig of neurilemoma and neurofibromatosis to start appropriate treatment at the early for the same .
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