This article on Epainassist.com has been reexamine by a medical master , as well as check for facts , to assure the lecturer the well potential accuracy .
We follow a strict editorial policy and we have a zero - tolerance policy regarding any level of plagiarism . Our clause are resourced from reputable online pages . This clause may contains scientific references . The numbers in the parentheses ( 1 , 2 , 3 ) are clickable link to match - reviewed scientific papers .
The feedback data link “ Was this Article Helpful ” on this Thomas Nelson Page can be used to account content that is not accurate , up - to - date or questionable in any manner .
This article does not provide aesculapian advice .
Abnormalities in the gene such as succinate dehydrogenase grinder - units B , C , and mutations in the RET gene are potential factors of paraganglioma.1,2
Paraganglioma is a uncommon type of malignant neoplastic disease and the intervention often depends on the location of the tumor and whether the abnormal growth is cancerous.3
Although there are no remedy for metastatic paraganglioma , the discussion aim in reducing the symptoms and prolonging the survival time.4
What Leads To Paraganglioma?
It is unclear what causes the condition however clinical cogitation demonstrate that Paraganglioma is due to a mutation in certain genes . This gene sport can enhance the risk of arise Paraganglioma . virtually 35%-40 % of all PGL / PCC is stimulate due to heritage as a part of familial paraganglioma syndrome .
However , multiple endocrine neoplasia case 2 , von Hippel - Lindau syndrome or neurofibromatosis also be given to uprise the disorder . Furthermore , a cistron defect can set off familial paraganglioma syndrome . Compared to sporadic forms , familial paragangliomas are inherit in an autosomal dominant pattern wherein just a transcript of the altered gene has the potential to raise the risk of exposure of develop malignant neoplastic disease .
genetic mutation in the SDHD factor have also been associated with a malignant paraganglioma . abnormality in the genes such as succinate dehydrogenase sub - units B , C , and mutations in the RET gene are potential factors of paraganglioma.1,2
Can Paraganglioma Be Cured?
Paraganglioma is a uncommon case of cancer and the treatment often depends on the location of the tumor and whether the unnatural growing is cancerous .
The diagnosis will betoken the abnormal increment of the disorder and identify whether the experimental condition is cancerous . handling aims in easing the symptoms ( blood pressure ) and control the spread of the cancerous cells . The treatment include
Medications To Control Hormone Levels - The primary object glass of using medications is to destroy the cancerous cells . Drugs maintain the blood pressure level levels , especially a eccentric of drug called alpha - blocking agent used in the combination of other drugs reduces the blood force per unit area and relax placid muscularity in the body.3
Surgery For The Removal Of Tumor - Surgery is used to altogether polish off the neoplasm cells let in the ones that have spread to dissimilar share of the human system . However , it is more decisive to control the parentage pressure before OR because increased blood pressure can lead in accident during any surgery or therapy
Radiation Therapy - Paraganglioma can be cure using in high spirits - intensity radioactivity therapy . This procedure is often helpful in both manipulate the tumor as well as ameliorate the symptoms .
Chemotherapy - This proficiency destruct the cancerous cellular phone and diminish the ability of tumor cells to breed and split up . When people are experiencing metastatic paraganglioma , chemotherapy is one of the most recommended options .
When the tumour is growing slowly , operating theatre will not be require , rather , radiation syndrome can be do to heal the term . Although medical studies state that there are no cures for metastatic paraganglioma , the discourse aims in reducing the symptom and sustain the survival time.4
Paraganglioma is a rare , benignant ( non - cancerous tumor ) that progresses very slowly and is often related to pheochromocytoma . The origination of the tumour is from the peripheral nervous scheme characterized by the output of surplus hormones called catecholamine .
catecholamine are internal secretion secrete by the adrenal glands ’ location on the prior portion of your kidney . They act both as neurotransmitter and hormones that serve the dead body respond to emphasis and fright . The internal secretion release is spark off during stress .
References :
Also record :
