Mechanism of Action of Sildenafil
Sildenafil works by relaxing muscle of blood vessel wall , which increases blood menses to the area by augment NO ( nitrous oxide ) and cGMP ( cyclic deoxyguanosine monophosphate ) . Sildenafil acts upon phosphodiesterase type 5 ( PDE5 ) enzyme that is specifically found in tissues of penis , lungs , eyes etc . Sildenafil works by hold to the active site of PDE5 , thus prevent it from the breakdown of cGMP making vascular smooth muscular tissue more sensitive to NO and cGMP , thus relaxes the blood vessels . This extend to erection in ED patients and improves exercise capacity in men and women in pulmonary hypertension type . Pulmonary hypertension is improved with pulmonary arterial walls liberalization ; therefore , it is used for its treatment .
What Is Pulmonary Hypertension?
pulmonic high blood pressure ( PH ) involves grand pressure in the vas of the lung . It is estimated to affect about 1 lakh multitude worldwide . Pulmonary hypertension is normally idiopathic ; however , it is mostly associated with some underlie chronic lung disease or chronic heart disease . It is associated with the symptoms of exertionalshortness of breath , fatigueanddizziness . It is noted that the forecast of affected role with pulmonary high blood pressure is very poor without any treatment ; patients live for only less than three age .
Why is Viagra used for Pulmonary Hypertension?
Revatio ( sildenafil ) was approved by FDA for the discussion of pulmonary hypertension after a 12 week subject field base on 277 patient role endure with pulmonary high blood pressure were tested with 20 mg , 40 mg and 80 mg sildenafil three times day by day . After the end of 12 weeks , all the group treated for dissimilar doses of sildenafil showed significant improvements against the ascendence group . In accession , to the improved lung pressure and heart run 94 % patients on sildenafil were still alive in a one - year long trial .
Thus , FDA okay the down in the mouth pane of sildenafil 20 magnesium three times daily as no particular dose had an advantage over one another . Pfizer plunge sildenafil 20 mg in the brand name of Revatio in 2005 . Revatio is the first oral drug that has been okay for the other intercession of pulmonary hypertension . Tracleer , is another drug that is used to treat this condition , but the effectuality of Revatio has not been evaluate in patients who are on Tracleer .
Along with the medication , it is advised to try medical assistance in emergency brake case of pulmonary hypertension . It is also advised for patients of pulmonic high blood pressure to continue active by walking , following a healthy diet , tension reduction , smoking cessation , and resting .
Side Effects of Revatio
The side effect of Revatio are similar to Viagra that are usually mild . The side effects admit concern , facial flushing , foolhardy , and diarrhea , increase susceptibleness to urinary tract infection , nasal congestion , insomnia , and nose bleeding . The side event involving vision includes blurred vision , sensitivity to Inner Light and/or tinge of blueish - dark-green vision know as cyanopsia and in super rare cases vision loss .
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